Details:

Alternative Title:
J Agric Food Chem
Publisher's site:
http://dx.doi.org/10.1021/acs.jafc.6b02478
Personal Author:
Isenberg, Samantha L. ; Carter, Melissa D. ; Hayes, Shelby R. ; Graham, Leigh Ann ; Johnson, Darryl ; ... More +
Isenberg, Samantha L. ; Carter, Melissa D. ; Hayes, Shelby R. ; Graham, Leigh Ann ; Johnson, Darryl ; Mathews, Thomas P. ; Harden, Leslie A. ; Takeoka, Gary R. ; Thomas, Jerry D. ; Pirkle, James L. ; Johnson, Rudolph C. Less -
Description:
Methylenecyclopropylglycine (MCPG) and hypoglycin A (HGA) are naturally occurring amino acids found in some soapberry fruits. Fatalities have been reported worldwide as a result of HGA ingestion, and exposure to MCPG has been implicated recently in the Asian outbreaks of hypoglycemic encephalopathy. In response to an outbreak linked to soapberry ingestion, the authors developed the first method to simultaneously quantify MCPG and HGA in soapberry fruits from 1 to 10 000 ppm of both toxins in dried fruit aril. Further, this is the first report of HGA in litchi, longan, and mamoncillo arils. This method is presented to specifically address the laboratory needs of public-health investigators in the hypoglycemic encephalitis outbreaks linked to soapberry fruit ingestion.
Subjects:
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Acer Aceraceae Ackee Aesculus Article Chromatography, High Pressure Liquid Cyclopropanes Cyclopropylamino Acids Fruit Glycine Hypoglycin A Hypoglycins Litchi Lychee Methylenecyclopropylalanine Methylenecyclopropylglycine Rambutan Sapindaceae Soapberry Tandem Mass Spectrometry
Source:
J Agric Food Chem. 64(27):5607-5613.
Pubmed ID:
27367968
Pubmed Central ID:
PMC5098216
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7fddac5e7f0ad53035f0950a111afe63558085edd130035288bda0ea369af882
Download URL:
https://stacks.cdc.gov/view/cdc/42721/cdc_42721_DS1.pdf
File Type:

Supporting Files

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