Quantification of Toxins in Soapberry (Sapindaceae) Arils: Hypoglycin A and Methylenecyclopropylglycine

Isenberg, Samantha L.; Carter, Melissa D.; Hayes, Shelby R.; Graham, Leigh Ann; Johnson, Darryl; Mathews, Thomas P.; Harden, Leslie A.; Takeoka, Gary R.; Thomas, Jerry D.; Pirkle, James L.; Johnson, Rudolph C.

doi:10.1021/acs.jafc.6b02478

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Quantification of Toxins in Soapberry (Sapindaceae) Arils: Hypoglycin A and Methylenecyclopropylglycine

Published Date:

Jul 01 2016

Publisher's site:

http://dx.doi.org/10.1021/acs.jafc.6b02478

Source:

J Agric Food Chem. 64(27):5607-5613.

[PDF-867.53 KB]

Details:

Alternative Title:

J Agric Food Chem

Personal Author:

Isenberg, Samantha L. ; Carter, Melissa D. ; Hayes, Shelby R. ; Graham, Leigh Ann ; Johnson, Darryl ; ... More ▼

Description:

Methylenecyclopropylglycine (MCPG) and hypoglycin A (HGA) are naturally occurring amino acids found in some soapberry fruits. Fatalities have been reported worldwide as a result of HGA ingestion, and exposure to MCPG has been implicated recently in the Asian outbreaks of hypoglycemic encephalopathy. In response to an outbreak linked to soapberry ingestion, the authors developed the first method to simultaneously quantify MCPG and HGA in soapberry fruits from 1 to 10 000 ppm of both toxins in dried fruit aril. Further, this is the first report of HGA in litchi, longan, and mamoncillo arils. This method is presented to specifically address the laboratory needs of public-health investigators in the hypoglycemic encephalitis outbreaks linked to soapberry fruit ingestion.

Subject:

[+]

Pubmed ID:

27367968

Pubmed Central ID:

PMC5098216

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

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Quantification of Toxins in Soapberry (Sapindaceae) Arils: Hypoglycin A and Methylenecyclopropylglycine

Quantification of Toxins in Soapberry (Sapindaceae) Arils: Hypoglycin A and Methylenecyclopropylglycine

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