Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain

Lahra, Monica M.; Martin, Irene; Demczuk, Walter; Jennison, Amy V.; Lee, Ken-Ichi; Nakayama, Shu-Ichi; Lefebvre, Brigitte; Longtin, Jean; Ward, Alison; Mulvey, Michael R.; Wi, Teodora; Ohnishi, Makoto; Whiley, David

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Cooperative Recognition of Internationally Disseminated Ceftriaxone-Resistant Neisseria gonorrhoeae Strain

Apr 2018
By Lahra, Monica M. ; Martin, Irene ; Demczuk, Walter ; ...
Source: Emerg Infect Dis. 24(4):735-740.

[PDF-703.13 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Lahra, Monica M. ; Martin, Irene ; Demczuk, Walter ; Jennison, Amy V. ; Lee, Ken-Ichi ; ... More +

Lahra, Monica M. ; Martin, Irene ; Demczuk, Walter ; Jennison, Amy V. ; Lee, Ken-Ichi ; Nakayama, Shu-Ichi ; Lefebvre, Brigitte ; Longtin, Jean ; Ward, Alison ; Mulvey, Michael R. ; Wi, Teodora ; Ohnishi, Makoto ; Whiley, David Less -
Description:

Ceftriaxone remains a first-line treatment for patients infected by Neisseria gonorrhoeae in most settings. We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). We report 2 instances of the FC428 clone in Australia in heterosexual men traveling from Asia. Our bioinformatic analyses included core single-nucleotide variation phylogeny and in silico molecular typing; phylogenetic analysis showed close genetic relatedness among all 5 isolates. Results showed multilocus sequence type 1903; N. gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) 233; and harboring of mosaic penA allele encoding alterations A311V and T483S (penA-60.001), associated with ceftriaxone resistance. Our results provide further evidence of international transmission of ceftriaxone-resistant N. gonorrhoeae. We recommend increasing awareness of international spread of this drug-resistant strain, strengthening surveillance to include identifying treatment failures and contacts, and strengthening international sharing of data.
Subjects:

[+]

Beta-Lactamase Inhibitors Beta-Lactam Resistance Ceftriaxone Genome, Bacterial Genomics Gonorrhea Humans Microbial Sensitivity Tests Neisseria Gonorrhoeae Phylogeny Polymorphism, Single Nucleotide Research
Source:

Emerg Infect Dis. 24(4):735-740.
Pubmed ID:

29553335
Pubmed Central ID:

PMC5875269
Document Type:

Journal Article
Place as Subject:

Canada ; Japan ; France ; Spain ; Australia ; ... More +

Canada ; Japan ; France ; Spain ; Australia ; China Less -
Location:

North America ; Asia ; Europe ; Oceania

North America ; Asia ; Europe ; Oceania Less -
Volume:

24
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:e18a0652c84b00c6a7f4cb02a23c98cf13b96deb5bb8fef28c0314df08d90214
Download URL:

https://stacks.cdc.gov/view/cdc/53079/cdc_53079_DS1.pdf
File Type:

	17-1873-F.gif	gif
	17-1873-F.jpg	jpeg
	17-1873-Techapp-s1.pdf	pdf
	17-1873.nxml	xml

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