Details:

• Alternative Title:
  Sex Transm Dis
• Personal Author:
  Pugsley, River A. ; Gadju, Gracia ; Young, Kaylah ; Rose, Cameron ; Haugan, Nan ; ... More +

  Pugsley, River A. ; Gadju, Gracia ; Young, Kaylah ; Rose, Cameron ; Haugan, Nan ; Vasiliu, Oana Less -
• Description:
  Background:
  
  Disseminated gonococcal infection (DGI), a complication of untreated gonorrhea, is rarely reported through routine surveillance. We sought to improve local surveillance system capacity to estimate and monitor the incidence of DGI in Virginia.
  
  Methods:
  
  We modified surveillance protocols to identify possible DGI cases using information extracted from gonorrhea case reports and performed provider follow-up using standardized case report forms to confirm DGI diagnosis and collect clinical information. Suspect cases included those with a laboratory report indicating sterile site of specimen collection (e.g. blood, synovial fluid) and/or intravenous (IV) treatment. We performed descriptive analyses to summarize characteristics of suspect and confirmed DGIs and estimated incidence.
  
  Results:
  
  After piloting protocols in 2018–2019, we identified 405 suspect DGI cases from 29,294 gonorrhea cases reported in 2020–21 (1.4%). We initiated investigations for 298 (73.6%) of the suspect cases, received provider responses for 105 (25.9%), and confirmed 19 (4.7%) DGI cases. Positive laboratory reports from non-mucosal sites were the most reliable predictor of confirmed DGI status, but most were not confirmed as DGI even when provider follow-up was successful. The confirmed and estimated incidence of DGI was 0.06% and 0.22% respectively. Sixteen (84%) of the confirmed cases were over 25 years of age, 3 (16%) were HIV-positive, and approximately half were male and non-Hispanic black. The majority (15, 74%) were hospitalized, and common manifestations included septic arthritis and bacteremia.
  
  Conclusions:
  
  We improved surveillance for DGI in Virginia while incurring minor programmatic costs. Additional efforts to improve the completeness and quality of surveillance data for DGI are needed.
  
  
• Subjects:
  [+]

  Arthritis, Infectious Female Gonorrhea Humans Male Neisseria Gonorrhoeae Virginia
• Keywords:
  [+]

  Disseminated Gonococcal Infection Gonorrhea Surveillance
• Source:
  Sex Transm Dis. 51(3):171-177
• Pubmed ID:
  38133574
• Pubmed Central ID:
  PMC10948019
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  [+]

  urn:sha256:7b31aa7879ccc1afecd99568abd78065004cf55bbabb50a9de14eabaab3ab46c
• File Type:

• Supporting Files:
  No Additional Files