Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans

Yamayoshi, Seiya; Kiso, Maki; Yasuhara, Atsuhiro; Ito, Mutsumi; Shu, Yuelong; Kawaoka, Yoshihiro

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Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans

Supporting Files

Apr 2018
By Yamayoshi, Seiya ; Kiso, Maki ; Yasuhara, Atsuhiro ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Yamayoshi, Seiya ; Kiso, Maki ; Yasuhara, Atsuhiro ; Ito, Mutsumi ; Shu, Yuelong ; Kawaoka, Yoshihiro
Description:

To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.
Subjects:

Animals Dispatch Genes, Viral Humans Influenza, Human Influenza A Virus, H7N9 Subtype Mice Mino Acid Substitution Mutation Orthomyxoviridae Infections Virulence Virus Replication
Source:

Emerg Infect Dis. 24(4):746-750.
Pubmed ID:

29553313
Pubmed Central ID:

PMC5875272
Document Type:

Journal Article
Funding:

HHSN272201400008C/AI/NIAID NIH HHS/United States
Volume:

24
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:ee24ac0b035c434cdd257b74200867d86e6f6d6749ed7de5d9c5cf439fcf8c4f
Download URL:

https://stacks.cdc.gov/view/cdc/53062/cdc_53062_DS1.pdf
File Type:

[PDF - 2.73 MB ]

File Language:

English

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