Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Lutgring, Joseph D. ; Zhu, Wenming ; de Man, Tom J.B. ; Avillan, Johannetsy J. ; Anderson, Karen F. ; ... More +
Lutgring, Joseph D. ; Zhu, Wenming ; de Man, Tom J.B. ; Avillan, Johannetsy J. ; Anderson, Karen F. ; Lonsway, David R. ; Rowe, Lori A. ; Batra, Dhwani ; Rasheed, J. Kamile ; Limbago, Brandi M. Less -
Description:
Oxacillinase (OXA)-48-like carbapenemases remain relatively uncommon in the United States. We performed phenotypic and genotypic characterization of 30 Enterobacteriaceae producing OXA-48-like carbapenemases that were recovered from patients during 2010-2014. Isolates were collected from 12 states and not associated with outbreaks, although we could not exclude limited local transmission. The alleles β-lactamase OXA-181 (bla|) (43%), bla| (33%), and bla| (23%) were found. All isolates were resistant to ertapenem and showed positive results for the ertapenem and meropenem modified Hodge test and the modified carbapenem inactivation method; 73% showed a positive result for the Carba Nordmann-Poirel test. Whole-genome sequencing identified extended-spectrum β-lactamase genes in 93% of isolates. In all bla| isolates, the gene was on a ColKP3 plasmid. A total of 12 of 13 isolates harboring bla| contained the insertion sequence ΔISEcp1. In all isolates with bla|, the gene was located on a TN1999 transposon; these isolates also carried IncL/M plasmids.
Subjects:
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Anti-Bacterial Agents Antimicrobial Resistance Bacteria Beta-Lactamases Enterobacteriaceae Genotypic Characterization Oxa-48 Oxacillinase-48–Like Carbapenemases Phenotypic And Genotypic Characterization Of Enterobacteriaceae Producing Oxacillinase-48–Like Carbapenemases, United States Phenotypic Characterization Research
Source:
Emerg Infect Dis. 24(4):700-709.
Pubmed ID:
29553324
Pubmed Central ID:
PMC5875285
Document Type:
Journal Article
Place as Subject:
United States
Location:
North America
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:dd33ece129a8f4900fdf537785b3521dd9de05862ee551b3a4aafb6ed77486c4
Download URL:
https://stacks.cdc.gov/view/cdc/53059/cdc_53059_DS1.pdf
File Type:

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