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Phenotypic and Genotypic Characterization of Enterobacteriaceae Producing Oxacillinase-48–Like Carbapenemases, United States
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Apr 2018
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Source: Emerg Infect Dis. 24(4):700-709.
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Alternative Title:Emerg Infect Dis
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Description:Oxacillinase (OXA)-48-like carbapenemases remain relatively uncommon in the United States. We performed phenotypic and genotypic characterization of 30 Enterobacteriaceae producing OXA-48-like carbapenemases that were recovered from patients during 2010-2014. Isolates were collected from 12 states and not associated with outbreaks, although we could not exclude limited local transmission. The alleles β-lactamase OXA-181 (bla|) (43%), bla| (33%), and bla| (23%) were found. All isolates were resistant to ertapenem and showed positive results for the ertapenem and meropenem modified Hodge test and the modified carbapenem inactivation method; 73% showed a positive result for the Carba Nordmann-Poirel test. Whole-genome sequencing identified extended-spectrum β-lactamase genes in 93% of isolates. In all bla| isolates, the gene was on a ColKP3 plasmid. A total of 12 of 13 isolates harboring bla| contained the insertion sequence ΔISEcp1. In all isolates with bla|, the gene was located on a TN1999 transposon; these isolates also carried IncL/M plasmids.
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Pubmed ID:29553324
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Pubmed Central ID:PMC5875285
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Volume:24
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Issue:4
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