Artemisinin-Resistant Plasmodium falciparum with High Survival Rates, Uganda, 2014–2016

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ikeda, Mie ; Kaneko, Megumi ; Tachibana, Shin-Ichiro ; Balikagala, Betty ; Sakurai-Yatsushiro, Miki ; Yatsushiro, Shouki ; Takahashi, Nobuyuki ; Yamauchi, Masato ; Sekihara, Makoto ; Hashimoto, Muneaki ; Katuro, Osbert T. ; Olia, Alex ; Obwoya, Paul S. ; Auma, Mary A. ; Anywar, Denis A. ; Odongo-Aginya, Emmanuel I. ; Okello-Onen, Joseph ; Hirai, Makoto ; Ohashi, Jun ; Palacpac, Nirianne M.Q. ; Kataoka, Masatoshi ; Tsuboi, Takafumi ; Kimura, Eisaku ; Horii, Toshihiro ; Mita, Toshihiro
• Description:
  Because ≈90% of malaria cases occur in Africa, emergence of artemisinin-resistant Plasmodium falciparum in Africa poses a serious public health threat. To assess emergence of artemisinin-resistant parasites in Uganda during 2014-2016, we used the recently developed ex vivo ring-stage survival assay, which estimates ring-stage-specific P. falciparum susceptibility to artemisinin. We conducted 4 cross-sectional surveys to assess artemisinin sensitivity in Gulu, Uganda. Among 194 isolates, survival rates (ratio of viable drug-exposed parasites to drug-nonexposed controls) were high (>10%) for 4 isolates. Similar rates have been closely associated with delayed parasite clearance after drug treatment and are considered to be a proxy for the artemisinin-resistant phenotype. Of these, the PfKelch13 mutation was observed in only 1 isolate, A675V. Population genetics analysis suggested that these possibly artemisinin-resistant isolates originated in Africa. Large-scale surveillance of possibly artemisinin-resistant parasites in Africa would provide useful information about treatment outcomes and help regional malaria control.
• Subjects:
  Antimicrobial Resistance Artemisinin Drug Resistance Malaria Parasites Plasmodium Falciparum Research
• Source:
  Emerg Infect Dis. 24(4):718-726.
• Pubmed ID:
  29553316
• Pubmed Central ID:
  PMC5875287
• Document Type:
  Journal Article
• Place as Subject:
  Uganda
• Location:
  Africa
• Volume:
  24
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9b671418aeef87c65a3ec8ce5c7a9e6fe4b2c91d026d0cfe6981c774d0f7e7cb
• Download URL:
  https://stacks.cdc.gov/view/cdc/53051/cdc_53051_DS1.pdf
• File Type:
  [PDF - 1.51 MB ]