Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Ikeda, Mie ; Kaneko, Megumi ; Tachibana, Shin-Ichiro ; Balikagala, Betty ; Sakurai-Yatsushiro, Miki ; ... More +
Ikeda, Mie ; Kaneko, Megumi ; Tachibana, Shin-Ichiro ; Balikagala, Betty ; Sakurai-Yatsushiro, Miki ; Yatsushiro, Shouki ; Takahashi, Nobuyuki ; Yamauchi, Masato ; Sekihara, Makoto ; Hashimoto, Muneaki ; Katuro, Osbert T. ; Olia, Alex ; Obwoya, Paul S. ; Auma, Mary A. ; Anywar, Denis A. ; Odongo-Aginya, Emmanuel I. ; Okello-Onen, Joseph ; Hirai, Makoto ; Ohashi, Jun ; Palacpac, Nirianne M.Q. ; Kataoka, Masatoshi ; Tsuboi, Takafumi ; Kimura, Eisaku ; Horii, Toshihiro ; Mita, Toshihiro Less -
Description:
Because ≈90% of malaria cases occur in Africa, emergence of artemisinin-resistant Plasmodium falciparum in Africa poses a serious public health threat. To assess emergence of artemisinin-resistant parasites in Uganda during 2014-2016, we used the recently developed ex vivo ring-stage survival assay, which estimates ring-stage-specific P. falciparum susceptibility to artemisinin. We conducted 4 cross-sectional surveys to assess artemisinin sensitivity in Gulu, Uganda. Among 194 isolates, survival rates (ratio of viable drug-exposed parasites to drug-nonexposed controls) were high (>10%) for 4 isolates. Similar rates have been closely associated with delayed parasite clearance after drug treatment and are considered to be a proxy for the artemisinin-resistant phenotype. Of these, the PfKelch13 mutation was observed in only 1 isolate, A675V. Population genetics analysis suggested that these possibly artemisinin-resistant isolates originated in Africa. Large-scale surveillance of possibly artemisinin-resistant parasites in Africa would provide useful information about treatment outcomes and help regional malaria control.
Subject:
[+]
Antimicrobial Resistance
Artemisinin
Drug Resistance
Malaria
Parasites
Plasmodium Falciparum
Research

Source:
Emerg Infect Dis. 24(4):718-726.
Pubmed ID:
29553316
Pubmed Central ID:
PMC5875287
Document Type:
Journal Article
Place as Subject:
Uganda
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:9b671418aeef87c65a3ec8ce5c7a9e6fe4b2c91d026d0cfe6981c774d0f7e7cb
File Type:

Supporting Files

• 	17-0141-Techapp-s1.pdf	pdf
  	17-0141.nxml	xml
  	17-0141-F1.gif	gif
  	17-0141-F1.jpg	jpeg
  	17-0141-F2.gif	gif
  	17-0141-F2.jpg	jpeg
  	17-0141-F3.gif	gif
  	17-0141-F3.jpg	jpeg
  	17-0141-F4.gif	gif
  	17-0141-F4.jpg	jpeg

More +