Details:

Alternative Title:
Clin Infect Dis
Personal Author:
Thielen, Beth K. ; Friedlander, Hannah ; Bistodeau, Sarah ; Shu, Bo ; Lynch, Brian ; ... More +
Thielen, Beth K. ; Friedlander, Hannah ; Bistodeau, Sarah ; Shu, Bo ; Lynch, Brian ; Martin, Karen ; Bye, Erica ; Como-Sabetti, Kathyrn ; Boxrud, David ; Strain, Anna K. ; Chaves, Sandra S. ; Steffens, Andrea ; Fowlkes, Ashley L. ; Lindstrom, Stephen ; Lynfield, Ruth Less -
Description:
Background

Existing literature suggests that influenza C typically causes mild respiratory tract disease. However, clinical and epidemiological data are limited.

Methods

Four outpatient clinics and three hospitals submitted clinical data and respiratory specimens through a surveillance network for acute respiratory infection (ARI) during May 2013 through December 2016. Specimens were tested using multi-target nucleic acid amplification tests (NAAT) for 19–22 respiratory pathogens, including influenza C.

Results

Influenza C virus was detected among 59 of 10,202 (0.58%) hospitalized SARI cases and 11 of 2,282 (0.48%) outpatients. Most detections occurred from December to March, with 73% during the 2014–2015 season. Influenza C detections occurred among patients of all ages, with similar rates between inpatients and outpatients. The highest rate of detection occurred among children aged 6 to 24 months (1.2%). Among hospitalized cases, seven required intensive care. Medical co-morbidities were reported in 58% of hospitalized cases and all who required intensive care. At least one other respiratory pathogen was detected in 40 (66%) cases, most commonly rhinovirus/enterovirus (25%) and respiratory syncytial virus (RSV) (20%). The hemagglutinin-esterase-fusion (HEF) gene was sequenced in 37 specimens, and both C/Kanagawa and C/Sao Paulo lineages were detected in inpatients and outpatients.

Conclusions

We found seasonal circulation of influenza C with year-to-year variability. Detection was most frequent among young children, but occurred in all ages. Some cases positive for influenza C, particularly those with co-morbid conditions, had severe disease, suggesting a need for further study of the role of influenza C virus in the pathogenesis of respiratory disease.


Subject:
[+]
Acute Disease
Adolescent
Adult
Aged
Aged, 80 And Over
Article
Child
Child, Preschool
Female
Hospitalization
Humans
Infant
Infant, Newborn
Influenza, Human
Influenzavirus C
Inpatients
Male
Middle Aged
Minnesota
Outpatients
Respiratory Tract Infections
Seasons
Sentinel Surveillance
Young Adult

Source:
Clin Infect Dis. 66(7):1092-1098
Pubmed ID:
29069373
Pubmed Central ID:
PMC5862734
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ec6a86d960e15055923ec561930e760230a120f7fb88c673d0286980fb377528
File Type:

Supporting Files

• 	NIHMS924657-supplement-1.docx	docx
  	NIHMS924657-supplement-2.docx	docx
  	NIHMS924657-supplement-3.docx	docx
  	nihms924657.nxml	xml
  	nihms924657f1.gif	gif
  	nihms924657f1.jpg	jpeg

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