The role of lymphocyte proliferation tests in assessing occupational sensitization and disease

Details

• Alternative Title:
  Curr Opin Allergy Clin Immunol
• Personal Author:
  Hines, Stella E. ; Pacheco, Karin ; Maier, Lisa A.
• Description:
  Purpose of Review
  
  Lymphocyte proliferation testing (LPT) is used in diagnosing occupationally-acquired delayed-type hypersensitivity. It has been used in beryllium-health effects, and it role is expanding in metal allergy. It may find application in diagnosis of other sensitizers.
  
  Recent findings
  
  Use of the beryllium LPT (BeLPT) in medical surveillance identifies beryllium sensitization at low exposure with chronic beryllium disease (CBD) that leads to physiologic impairment and need for immunosuppressive medications. New studies indicate that both beryllium exposure and genetic variation are associated with increased risk of CBD. Borderline positive BeLPTs warrant inclusion into diagnostic algorithms. Furthermore, use of LPTs to diagnose metal allergy is being proposed in diagnosis of chromium allergy and hypersensitivity to surgical implants. New occupational sensitizers continue to be identified including metalworking fluids, the sterilizing agent ortho-phthalaldehyde and the solvent parachlorobenzotrifluoride. Use of LPT in occupational surveillance to these agents, and other known sensitizers may play expanding roles.
  
  Summary
  
  Lymphocyte proliferation testing serves a valuable role in diagnosing occupational sensitization, as demonstrated with beryllium-health effects, as cases continue to be found at low exposure levels. The use of LPTs in diagnosing contact allergy is expanding, and new applications may be identified in human and animal studies.
  
  
• Subjects:
  Allergens Animals Berylliosis Beryllium Chronic Disease Female Humans Hypersensitivity Lymphocyte Activation Male Mice O-Phthalaldehyde Occupational Diseases Occupational Exposure

  More +
• Source:
  Curr Opin Allergy Clin Immunol. 12(2):102-110.
• Pubmed ID:
  22306552
• Pubmed Central ID:
  PMC5854495
• Document Type:
  Journal Article
• Funding:
  T42 OH009229/OH/NIOSH CDC HHS/United States ; UL1 RR025780/RR/NCRR NIH HHS/United States
• Volume:
  12
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a8f6799063c1c693567669e57368f6673d08194166d6141e5ac0da1eace75d06
• Download URL:
  https://stacks.cdc.gov/view/cdc/52556/cdc_52556_DS1.pdf
• File Type:
  [PDF - 323.71 KB ]