Analysis of Single Nucleotide Polymorphisms in Chronic Beryllium Disease

Details

• Journal Article:
  Respiratory Research
• Personal Author:
  Frye, Björn C. ; Gaede, Karoline I. ; Monos, Dimitri S. ; Müller-Quernheim, Joachim ; Noth, Rainer ; Nothnagel, Michael ; Rosenman, Kenneth D. ; Rossman, Milton D. ; Saltini, Cesare ; Schreiber, Stefan ; Schuler, Christine R. ; Wegner, Ralf ; Weston, Ainsley ; Zissel, Gernot
• Description:
  Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts of beryllium-exposed persons was analysed, no statistically relevant association between any SNP and CBD could be verified. Notably, some SNPs exhibit inverse OR for beryllium sensitization and CBD with nominally statistical significance, which allows hypothesizing about pathophysiological role of genes for the disease triggering and development. [Description provided by NIOSH]
• Subjects:
  Berylliosis Beryllium Butyrophilins Chronic Disease Cohort Studies DNA Genetics Hypersensitivity Occupational Exposure Occupational Health Polymorphism, Single Nucleotide Safety

  More +
• Keywords:
  Author Keywords: Sarcoidosis; Berylliosis Chronic; Beryllium Diesase; Genetic; Annexin A11; BTNL2 Sarcoidosis; Beryllium Disease; Genetics; Genes; Morphology; Genotype; Occupational Exposure; Employee Exposure; Cohort Studies; Sensitization;
• Source:
  Respir Res 2021 Apr; 22:107
• ISSN:
  1465-9921
• Pubmed ID:
  33863318
• Pubmed Central ID:
  PMC8051053
• Document Type:
  Text
• Funding:
  Mu692/7-1/Deutscher Forschungsgemeinschaft / German Research Foundation/
• Genre:
  Journal Article
• Place as Subject:
  Florida ; Michigan ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  5 pdf pages
• Volume:
  22
• NIOSHTIC Number:
  nn:20062598
• Contact Point Address:
  Joachim Müller-Quernheim, Department of Pneumology, Faculty of Medicine, Medical Center University of Freiburg, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany
• Email:
  joachim.mueller-quernheim@uniklinik-freiburg.de
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health CDC Public Access
• Main Document Checksum:
  urn:sha-512:4d7414ee4eca48bdfa3b87c3236ff54d70b69c55b5bc2c41a0d61d26d925ef847bb9ca97eb785e4cc18906cc9c9f68aac5fee6415f56c6d2ad7e4b659f9b59ab
• Download URL:
  https://stacks.cdc.gov/view/cdc/106302/cdc_106302_DS1.pdf
• File Type:
  [PDF - 819.54 KB ]