Analysis of single nucleotide polymorphisms in chronic beryllium disease

Details

• Alternative Title:
  Respir Res
• Personal Author:
  Frye, Björn C. ; Gaede, Karoline I. ; Saltini, Cesare ; Rossman, Milton D. ; Monos, Dimitri S. ; Rosenman, Ken D. ; Schuler, Christine R. ; Weston, Ainsley ; Wegner, Ralf ; Noth, Rainer ; Zissel, Gernot ; Schreiber, Stefan ; Nothnagel, Michael ; Müller-Quernheim, Joachim
• Description:
  Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts of beryllium-exposed persons was analysed, no statistically relevant association between any SNP and CBD could be verified. Notably, some SNPs exhibit inverse OR for beryllium sensitization and CBD with nominally statistical significance, which allows hypothesizing about pathophysiological role of genes for the disease triggering and development.
• Subjects:
  Berylliosis Beryllium Butyrophilins Chronic Disease DNA Female Humans Male Occupational Exposure Polymorphism, Single Nucleotide
• Source:
  Respir Res. 22
• Pubmed ID:
  33863318
• Pubmed Central ID:
  PMC8051053
• Document Type:
  Journal Article
• Funding:
  Mu692/7-1/Deutscher Forschungsgemeinschaft / German Research Foundation/
• Genre:
  Letter
• Volume:
  22
• NIOSHTIC Number:
  nn:20062598
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4d7414ee4eca48bdfa3b87c3236ff54d70b69c55b5bc2c41a0d61d26d925ef847bb9ca97eb785e4cc18906cc9c9f68aac5fee6415f56c6d2ad7e4b659f9b59ab
• Download URL:
  https://stacks.cdc.gov/view/cdc/106302/cdc_106302_DS1.pdf
• File Type:
  [PDF - 819.54 KB ]