The Association Between HLA-DPB1Glu69 and Chronic Beryllium Disease and Beryllium Sensitization

Details

• Personal Author:
  Ensey JS ; Kreiss, Kathleen ; McCanlies EC ; Schuler, Christine R. ; Weston A
• Description:
  Several case-control studies have found an association between chronic beryllium disease (CBD) and HLA-DPB1 gene variants. However, the relationship between HLA-DPB1 and beryllium sensitization, and whether the presence of one or two HLA-DPB1(Glu69) alleles is differentially associated with CBD and beryllium sensitization have not been completely resolved. Restriction fragment length polymorphism (RFLP) analysis was used to address these questions in a large population-based cohort consisting of 884 beryllium workers (90 with CBD, 64 beryllium sensitized). HLA-DPB1(Glu69) was associated with both CBD (OR = 9.4; 95% CI = 5.4, 16.6) and sensitization (OR = 3.3, 95% CI = 1.9, 5.9). Further, workers with CBD and sensitization were more likely to be homozygous HLA-DPB1(Glu69) compared to workers without disease or sensitization (P < 0.001). Follow-up of this cohort, scrutiny of HLA-DPB1 haplotypes, and evaluation of gene-environment and gene-gene interactions will be important for fully understanding the immunogenetic nature of this occupational disease. [Description provided by NIOSH]
• Subjects:
  Beryllium Case Reports Chronic Disease Genetics Hypersensitivity Occupational Diseases Occupational Exposure Occupational Health Safety
• Keywords:
  Author Keywords: Berylliosis Beryllium Beryllium-compounds Beryllium-disease Case-studies Chronic-degenerative-diseases Chronic Beryllium Disease Genes HLA-DP Antigens Occupational-diseases Occupational-exposure Occupational Epidemiology Sensitization Workers

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  95-103
• Volume:
  46
• Issue:
  2
• NIOSHTIC Number:
  nn:20025456
• Citation:
  Am J Ind Med 2004 Aug; 46(2):95-103
• Contact Point Address:
  Ainsley Weston, NIOSH/HELD/TMBB, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  agw8@cdc.gov
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4ce249da1b25f5159b19cbf96aa8cba7b4acd3775c6cc9c9acbf6a7cb5cd7232d2698e07e50b4959826e378b507097b9fdcfa41d1e8e7a231f8e309ad951bbcd
• Download URL:
  https://stacks.cdc.gov/view/cdc/196813/cdc_196813_DS1.pdf
• File Type:
  [PDF - 188.78 KB ]