Details:

Alternative Title:
Osteoarthritis Cartilage
Publisher's site:
http://dx.doi.org/10.1016/j.joca.2017.07.007
Personal Author:
Goode, Adam P. ; Nelson, Amanda E. ; Kraus, Virginia B. ; Renner, Jordan B. ; Jordan, Joanne M.
Goode, Adam P. ; Nelson, Amanda E. ; Kraus, Virginia B. ; Renner, Jordan B. ; Jordan, Joanne M. Less -
Description:
Objective

To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA.

Design

A cross-sectional analysis of data from 555 participants in the Johnston County Osteoarthritis Project was performed. Lumbar spine levels were graded by severity (OST and DSN) and presence (FOA) of degeneration. Biomarkers included hyaluronan (HA) and type II collagen (CTX-II). Adjusted risk ratios (aRRR) were estimated using multinomial regression, with adjustment for age, race, sex, body mass index (BMI), and radiographic OA (knee, hip, hand). Interactions were tested between sex, race and low back symptoms.

Results

FOA only was present in 22.4%, 14.5% had spine OA only, and 34.6% had the combination of FOA and spine OA. Compared to the reference group of neither FOA or spine OA, a one unit higher ln HA level was associated with 31% higher relative risk ratio (RRR=1.31 ((95% 1.03, 1.67)) of having FOA only, while, a one unit higher ln uCTX-II level was associated with 84% higher relative risk ratio (RRR=1.84 ((95% CI 1.19, 2.84)) of having spine OA only. No significant interactions were identified.

Conclusion

Interestingly, OA affecting the synovial facet joint was associated with a marker of inflammation (HA). Spine OA, affecting intervertebral discs that contain collagen type II, was associated with a marker reflecting collagen type II degradation (CTX-II). These findings suggest that biomarkers may reflect the different pathophysiologic processes of lumbar spine OA phenotypes.


Subject:
[+]
Aged
Article
Biomarkers
Collagen Type II
Cross-Sectional Studies
Female
Humans
Intervertebral Disc
Lumbar Vertebrae
Male
Middle Aged
Osteoarthritis, Spine
Osteophyte
Phenotype
Radiography
Zygapophyseal Joint

Source:
Osteoarthritis Cartilage. 25(10):1672-1679.
Pubmed ID:
28711584
Pubmed Central ID:
PMC5605465
Document Type:
Journal Article
Funding:
L30 AR057661/AR/NIAMS NIH HHS/United States ; P30 AG028716/AG/NIA NIH HHS/United States ; P60 AR049465/AR/NIAMS NIH HHS/United States ; U01 DP006266/DP/NCCDPHP CDC HHS/United States
L30 AR057661/AR/NIAMS NIH HHS/United States ; P30 AG028716/AG/NIA NIH HHS/United States ; P60 AR049465/AR/NIAMS NIH HHS/United States ; U01 DP006266/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1674161d4854ba7000c149093578766096fabcb94deb0f8e299522984bf32355
File Type:

Supporting Files

• 	NIHMS896545-supplement-s1.docx	docx
  	nihms896545.nxml	xml
  	nihms896545f1.gif	gif
  	nihms896545f1.jpg	jpeg

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