CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: The Johnston County Osteoarthritis Project
-
Jul 12 2017
-
-
Source: Osteoarthritis Cartilage. 25(10):1672-1679.
[PDF-287.27 KB]
Details:
-
Alternative Title:Osteoarthritis Cartilage
-
Personal Author:
-
Description:Objective
To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA.
Design
A cross-sectional analysis of data from 555 participants in the Johnston County Osteoarthritis Project was performed. Lumbar spine levels were graded by severity (OST and DSN) and presence (FOA) of degeneration. Biomarkers included hyaluronan (HA) and type II collagen (CTX-II). Adjusted risk ratios (aRRR) were estimated using multinomial regression, with adjustment for age, race, sex, body mass index (BMI), and radiographic OA (knee, hip, hand). Interactions were tested between sex, race and low back symptoms.
Results
FOA only was present in 22.4%, 14.5% had spine OA only, and 34.6% had the combination of FOA and spine OA. Compared to the reference group of neither FOA or spine OA, a one unit higher ln HA level was associated with 31% higher relative risk ratio (RRR=1.31 ((95% 1.03, 1.67)) of having FOA only, while, a one unit higher ln uCTX-II level was associated with 84% higher relative risk ratio (RRR=1.84 ((95% CI 1.19, 2.84)) of having spine OA only. No significant interactions were identified.
Conclusion
Interestingly, OA affecting the synovial facet joint was associated with a marker of inflammation (HA). Spine OA, affecting intervertebral discs that contain collagen type II, was associated with a marker reflecting collagen type II degradation (CTX-II). These findings suggest that biomarkers may reflect the different pathophysiologic processes of lumbar spine OA phenotypes.
-
Subjects:
-
Source:
-
Pubmed ID:28711584
-
Pubmed Central ID:PMC5605465
-
Document Type:
-
Funding:
-
Volume:25
-
Issue:10
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
