Details:

Alternative Title:
Arthritis Care Res (Hoboken)
Publisher's site:
http://dx.doi.org/10.1002/acr.23918
Personal Author:
Goode, Adam P. ; Cleveland, Rebecca J. ; George, Steven Z. ; Kraus, Virginia B. ; Schwartz, Todd A. ; ... More +
Goode, Adam P. ; Cleveland, Rebecca J. ; George, Steven Z. ; Kraus, Virginia B. ; Schwartz, Todd A. ; Gracely, Richard H. ; Jordan, Joanne M. ; Golightly, Yvonne M. Less -
Description:
Objective:

Determine if associations between demographic, appendicular joint osteoarthritis (OA), clinical characteristics reflect different phenotypes of OA in the lumbar spine.

Methods:

Participants were from the Johnston County OA Project. Demographics consisted of age, sex, and race (White and African American [AA]) and clinical characteristics consisted of body mass index (BMI), low back pain and injury, and knee, hip and hand osteoarthritis (OA). Participants were categorized as spine OA (SOA), facet joint OA (FOA), both SOA and FOA, or neither SOA nor FOA (referent group). Multinomial regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI).

Results:

The average age (n=1,793) was 66.2 years (SD=10.1) and BMI was 30.7 (SD=6.2). A majority (63.8%) were women (n=1,144) and 31.8% (n=570) AA. Neither SOA nor FOA was present in 18.0%; 22.8% had FOA, 13.2% had SOA and 46.0% had both SOA and FOA. In adjusted analyses, AA were less likely to have FOA (OR=0.68 95% CI 0.49, 0.95) and both SOA and FOA (OR=0.51 95% CI 0.37, 0.70). Women were more likely to have FOA (OR=1.71 95% CI 1.24, 2.36). BMI ≥30 kg/m2 was associated with FOA (OR=1.76 95% CI 1.28, 2.42) and both SOA and FOA (OR=1.85 95% CI 1.37, 2.51). Knee OA was associated with all three groups while lower back injury was associated with only SOA. Participants with hip OA were less likely to have FOA.

Conclusion:

Race, sex, BMI, hip OA, and lower back injury may inform different OA phenotypes in the lumbar spine.


Subjects:
[+]
Adult Aged Article Female Humans Lumbar Vertebrae Male Middle Aged North Carolina Osteoarthritis, Spine Phenotype
Source:
Arthritis Care Res (Hoboken). 72(7):974-981
Pubmed ID:
31058435
Pubmed Central ID:
PMC6834338
Document Type:
Journal Article
Funding:
R01 AR067743/AR/NIAMS NIH HHSUnited States/ ; P60 AR049465/AR/NIAMS NIH HHSUnited States/ ; U01 DP006266/DP/NCCDPHP CDC HHSUnited States/ ; P60 AR030701/AR/NIAMS NIH HHSUnited States/ ; R01 AR075399/AR/NIAMS NIH HHSUnited States/ ; ... More +
R01 AR067743/AR/NIAMS NIH HHSUnited States/ ; P60 AR049465/AR/NIAMS NIH HHSUnited States/ ; U01 DP006266/DP/NCCDPHP CDC HHSUnited States/ ; P60 AR030701/AR/NIAMS NIH HHSUnited States/ ; R01 AR075399/AR/NIAMS NIH HHSUnited States/ ; U01DP006266/ACL/ACL HHSUnited States/ ; P60 AR064166/AR/NIAMS NIH HHSUnited States/ ; R01 AR071440/AR/NIAMS NIH HHSUnited States/ ; P30 AG028716/AG/NIA NIH HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7d45f012a4ba061477c3842ca8bb7f82a75739112fbd621272c0f357f2b45d27
Download URL:
https://stacks.cdc.gov/view/cdc/85751/cdc_85751_DS1.pdf
File Type:

Supporting Files

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