Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015

Nguyen, Duc T.; Teeter, Larry D.; Graves, Julie; Graviss, Edward A.

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Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015

Supporting Files Public Domain

Mar 2018
By Nguyen, Duc T. ; Teeter, Larry D. ; Graves, Julie ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Nguyen, Duc T. ; Teeter, Larry D. ; Graves, Julie ; Graviss, Edward A.
Description:

Interferon-γ release assays (IGRAs) are the preferred diagnostic test for tuberculosis (TB) infection in at-risk populations in developed countries. However, IGRAs have high false-negative rates in patients with TB disease. Population-based studies assessing the factors associated with negative IGRA results in TB patients have not been performed. Using statewide TB surveillance data of culture-confirmed TB patients in Texas, USA, during 2013-2015, we describe the patient characteristics and treatment outcomes associated with false-negative IGRA results. Among 2,854 TB patients, 1,527 (53.5%) had an IGRA result; 97.4% (1,487/1,527) of those had a positive (87.7%) or negative (12.3%) result. Older age, HIV co-infection, non-Hispanic white race/ethnicity, and being tested with T-SPOT.TB were associated with negative IGRA results. TB patients with negative IGRA results had a higher mortality, potentially due to delayed treatment. Healthcare providers should consider these risk factors when making decisions for patients with suspected TB and negative IGRA results and potentially provide treatment.
Subjects:

Adult Aged Female History, 21st Century Humans Interferon-gamma Release Tests Male Middle Aged Mycobacterium Tuberculosis Odds Ratio Proportional Hazards Models Research Tuberculosis/diagnosis Tuberculosis/epidemiology Tuberculosis/history
Source:

Emerg Infect Dis. 24(3):534-540.
Pubmed ID:

29460756
Pubmed Central ID:

PMC5823348
Document Type:

Journal Article
Place as Subject:

Texas
Location:

North America
Volume:

24
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:07a9545fe54d64d34ddcc56eface95867896a85ab7e689ab01c65efe2fe2c9b2
Download URL:

https://stacks.cdc.gov/view/cdc/52197/cdc_52197_DS1.pdf
File Type:

[PDF - 2.00 MB ]

File Language:

English

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