Influenza Vaccination and Incident Tuberculosis among Elderly Persons, Taiwan

Yen, Yung-Feng; Pan, Sheng-Wei; Su, Vincent Yi-Fong; Chuang, Pei-Hung; Feng, Jia-Yih; Su, Wei-Juin

i

Influenza Vaccination and Incident Tuberculosis among Elderly Persons, Taiwan

Supporting Files Public Domain

Mar 2018
By Yen, Yung-Feng ; Pan, Sheng-Wei ; Su, Vincent Yi-Fong ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Yen, Yung-Feng ; Pan, Sheng-Wei ; Su, Vincent Yi-Fong ; Chuang, Pei-Hung ; Feng, Jia-Yih ; Su, Wei-Juin
Description:

Experimental studies have demonstrated that influenza vaccination may protect against tuberculosis (TB) through a Th17 response. This nationwide cohort study aimed to evaluate the association of influenza vaccination with incident TB among elderly persons in Taiwan. This 2005-2012 study included 99,982 elderly persons (64,290 vaccinated and 35,692 unvaccinated) from the Taiwan National Health Insurance Research Database. During the 738,367 person-years of follow-up, 1,141 (1.14%) persons had incident TB. The cumulative incidences of TB were 145.2 cases/100,000 person-years among vaccinated elderly persons and 175.5 cases/100,000 person-years among unvaccinated elderly persons (p = 0.002). The time-dependent Cox proportional hazards model revealed that influenza vaccination was an independent protective factor for incident TB. Our results suggest that influenza vaccination is associated with a lower risk of incident TB among elderly persons in Taiwan. Further investigation of biologic mechanisms is warranted.
Subjects:

Aged Aged, 80 And Over Age Factors Comorbidity Female Humans Incidence Influenza, Human/epidemiology Influenza, Human/prevention & Control Influenza Vaccines Male Population Surveillance Reproducibility Of Results Research Risk Factors Tuberculosis/diagnosis Tuberculosis/epidemiology Vaccination
Source:

Emerg Infect Dis. 24(3):498-505.
Pubmed ID:

29460733
Pubmed Central ID:

PMC5823323
Document Type:

Journal Article
Place as Subject:

Taiwan
Location:

Asia
Volume:

24
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:f46eba93ede0923f1bfbb99f4ff23ff1afb839d008d02b678b832062eb127148
Download URL:

https://stacks.cdc.gov/view/cdc/52172/cdc_52172_DS1.pdf
File Type:

[PDF - 1.13 MB ]

File Language:

English

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