Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Yen, Yung-Feng ; Pan, Sheng-Wei ; Su, Vincent Yi-Fong ; Chuang, Pei-Hung ; Feng, Jia-Yih ; ... More +
Yen, Yung-Feng ; Pan, Sheng-Wei ; Su, Vincent Yi-Fong ; Chuang, Pei-Hung ; Feng, Jia-Yih ; Su, Wei-Juin Less -
Description:
Experimental studies have demonstrated that influenza vaccination may protect against tuberculosis (TB) through a Th17 response. This nationwide cohort study aimed to evaluate the association of influenza vaccination with incident TB among elderly persons in Taiwan. This 2005-2012 study included 99,982 elderly persons (64,290 vaccinated and 35,692 unvaccinated) from the Taiwan National Health Insurance Research Database. During the 738,367 person-years of follow-up, 1,141 (1.14%) persons had incident TB. The cumulative incidences of TB were 145.2 cases/100,000 person-years among vaccinated elderly persons and 175.5 cases/100,000 person-years among unvaccinated elderly persons (p = 0.002). The time-dependent Cox proportional hazards model revealed that influenza vaccination was an independent protective factor for incident TB. Our results suggest that influenza vaccination is associated with a lower risk of incident TB among elderly persons in Taiwan. Further investigation of biologic mechanisms is warranted.
Subject:
[+]
Aged
Aged, 80 And Over
Age Factors
Comorbidity
Female
Humans
Incidence
Influenza, Human/epidemiology
Influenza, Human/prevention & Control
Influenza Vaccines
Male
Population Surveillance
Reproducibility Of Results
Research
Risk Factors
Tuberculosis/diagnosis
Tuberculosis/epidemiology
Vaccination

Source:
Emerg Infect Dis. 24(3):498-505.
Pubmed ID:
29460733
Pubmed Central ID:
PMC5823323
Document Type:
Journal Article
Place as Subject:
Taiwan
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:f46eba93ede0923f1bfbb99f4ff23ff1afb839d008d02b678b832062eb127148
File Type:

Supporting Files

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