Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study

Lee, Eunice Y.; Lin, Jue; Noth, Elizabeth M.; Hammond, S. Katharine; Nadeau, Kari C.; Eisen, Ellen A.; Balmes, John R.

doi:10.1097/JOM.0000000000000996

i

Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study

Supporting Files

5 2017 ; 5-2017
By Lee, Eunice Y. ; Lin, Jue ; Noth, Elizabeth M.
http://dx.doi.org/10.1097/JOM.0000000000000996
Available in CDC Stacks on 2018-05-01T00:00:00Z

File Language:

English

Details

Alternative Title:

J Occup Environ Med
Personal Author:

Lee, Eunice Y. ; Lin, Jue ; Noth, Elizabeth M. ; Hammond, S. Katharine ; Nadeau, Kari C. ; Eisen, Ellen A. ; Balmes, John R.
Description:

Objective ; The main objective of this pilot study was to gather preliminary information about how telomere length (TL) varies in relation to exposure to polycyclic aromatic hydrocarbons (PAHs) in children living in a highly polluted city. ; Methods ; We conducted a cross-sectional study of children living in Fresno, California (n=14). Subjects with and without asthma were selected based on their annual average PAH level in the 12-months prior to their blood draw. We measured relative telomere length from peripheral blood mononuclear cells (PBMC). ; Results ; We found an inverse linear relationship between average PAH level and telomere length (TL) (R2 = 0.69), as well as between age and TL (R2 = 0.21). Asthmatics had shorter mean telomere length than non-asthmatics (TLasthmatic=1.13, TLnon-asthmatic=1.29). ; Conclusions ; These preliminary findings suggest that exposure to ambient PAH may play a role in telomere shortening.
Keywords:
Source:

J Occup Environ Med. 59(5):446-452
Pubmed ID:

28486341
Pubmed Central ID:

PMC5424623
Document Type:

Journal Article
Funding:

T42 OH008429/OH/NIOSH CDC HHSUnited States/ ; U01 AI147462/AI/NIAID NIH HHSUnited States/ ; R01 ES020926/ES/NIEHS NIH HHSUnited States/ ; P01 ES022849/ES/NIEHS NIH HHSUnited States/ ; R01 HL081521/HL/NHLBI NIH HHSUnited States/ ; P20 ES018173/ES/NIEHS NIH HHSUnited States/
Volume:

59
Issue:

5
Download URL:

https://stacks.cdc.gov/view/cdc/52114/cdc_52114_DS1.pdf
File Type:

[PDF - 1.00 MB]
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:3c10438f3203d1008c61caffa12b843d92846ade5832b51f25a3091a4b52898f

File Language:

English

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