Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Lee, Eunice Y. ; Lin, Jue ; Noth, Elizabeth M. ; Hammond, S. Katharine ; Nadeau, Kari C. ; Eisen, Ellen A. ; Balmes, John R.
• Description:
  Objective
  
  The main objective of this pilot study was to gather preliminary information about how telomere length (TL) varies in relation to exposure to polycyclic aromatic hydrocarbons (PAHs) in children living in a highly polluted city.
  
  Methods
  
  We conducted a cross-sectional study of children living in Fresno, California (n=14). Subjects with and without asthma were selected based on their annual average PAH level in the 12-months prior to their blood draw. We measured relative telomere length from peripheral blood mononuclear cells (PBMC).
  
  Results
  
  We found an inverse linear relationship between average PAH level and telomere length (TL) (R2 = 0.69), as well as between age and TL (R2 = 0.21). Asthmatics had shorter mean telomere length than non-asthmatics (TLasthmatic=1.13, TLnon-asthmatic=1.29).
  
  Conclusions
  
  These preliminary findings suggest that exposure to ambient PAH may play a role in telomere shortening.
  
  
• Keywords:
  Adolescent Air Pollution Asthma California Child Cross-Sectional Studies Environmental Exposure Female Humans Male Motor Vehicles Pilot Projects Polycyclic Aromatic Hydrocarbons Telomere Homeostasis Telomere Shortening Vehicle Emissions

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• Source:
  J Occup Environ Med. 59(5):446-452
• Pubmed ID:
  28486341
• Pubmed Central ID:
  PMC5424623
• Document Type:
  Journal Article
• Funding:
  T42 OH008429/OH/NIOSH CDC HHSUnited States/ ; U01 AI147462/AI/NIAID NIH HHSUnited States/ ; R01 ES020926/ES/NIEHS NIH HHSUnited States/ ; P01 ES022849/ES/NIEHS NIH HHSUnited States/ ; R01 HL081521/HL/NHLBI NIH HHSUnited States/ ; P20 ES018173/ES/NIEHS NIH HHSUnited States/
• Volume:
  59
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3c10438f3203d1008c61caffa12b843d92846ade5832b51f25a3091a4b52898f
• Download URL:
  https://stacks.cdc.gov/view/cdc/52114/cdc_52114_DS1.pdf
• File Type:
  [PDF - 1.00 MB ]