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Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study
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5 2017
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Source: J Occup Environ Med. 59(5):446-452
[PDF-1.00 MB]
Details:
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Alternative Title:J Occup Environ Med
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Personal Author:
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Description:Objective
The main objective of this pilot study was to gather preliminary information about how telomere length (TL) varies in relation to exposure to polycyclic aromatic hydrocarbons (PAHs) in children living in a highly polluted city.
Methods
We conducted a cross-sectional study of children living in Fresno, California (n=14). Subjects with and without asthma were selected based on their annual average PAH level in the 12-months prior to their blood draw. We measured relative telomere length from peripheral blood mononuclear cells (PBMC).
Results
We found an inverse linear relationship between average PAH level and telomere length (TL) (R2 = 0.69), as well as between age and TL (R2 = 0.21). Asthmatics had shorter mean telomere length than non-asthmatics (TLasthmatic=1.13, TLnon-asthmatic=1.29).
Conclusions
These preliminary findings suggest that exposure to ambient PAH may play a role in telomere shortening.
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Pubmed ID:28486341
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Pubmed Central ID:PMC5424623
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Funding:
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Volume:59
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Issue:5
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