Spread of Meropenem-Resistant Streptococcus pneumoniae Serotype 15A-ST63 Clone in Japan, 2012–2014

Nakano, Satoshi; Fujisawa, Takao; Ito, Yutaka; Chang, Bin; Matsumura, Yasufumi; Yamamoto, Masaki; Nagao, Miki; Suga, Shigeru; Ohnishi, Makoto; Ichiyama, Satoshi

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Spread of Meropenem-Resistant Streptococcus pneumoniae Serotype 15A-ST63 Clone in Japan, 2012–2014

Published Date:

Feb 2018

Source:

Emerg Infect Dis. 24(2):275-283.

[PDF-1.86 MB]

Details:

Personal Authors:

Nakano, Satoshi ; Fujisawa, Takao ; Ito, Yutaka ; Chang, Bin ; Matsumura, Yasufumi ; ... More ▼

Keywords:

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Pubmed ID:

29350141

Pubmed Central ID:

PMC5782878

Description:

After the introduction of pneumococcal conjugate vaccines, the incidence of pneumococcal infections due to meropenem-resistant serotype 15A-ST63 strains increased in Japan. By using whole-genome sequencing and comparing sequences with those of clones from the United Kingdom, the United States, and Canada, we clarified the traits of the serotype 15A-ST63 clone. Our analysis revealed that the meropenem-resistant serotype 15A-ST63 strains from Japan originated from meropenem-susceptible strains from Japan. Recombination site prediction analysis showed that the meropenem-resistant strain-specific recombination regions included the pbp1a and pbp2b regions. A detailed analysis of the composition of these genes indicated that resistance seems to be caused by pbp1a recombination. The pbp1a gene in meropenem-resistant isolates was identical to that in multidrug (including meropenem)-resistant serotype 19A-ST320 pneumococci, which have spread in the United States. The global spread of pneumococci of this lineage is noteworthy because serotype 15A is not included in the currently used 13-valent pneumococcal conjugate vaccine.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

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