Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Nakano, Satoshi; Fujisawa, Takao; Ito, Yutaka; Chang, Bin; Matsumura, Yasufumi; ... More +
Nakano, Satoshi; Fujisawa, Takao; Ito, Yutaka; Chang, Bin; Matsumura, Yasufumi; Yamamoto, Masaki; Nagao, Miki; Suga, Shigeru; Ohnishi, Makoto; Ichiyama, Satoshi; Less -
Description:
After the introduction of pneumococcal conjugate vaccines, the incidence of pneumococcal infections due to meropenem-resistant serotype 15A-ST63 strains increased in Japan. By using whole-genome sequencing and comparing sequences with those of clones from the United Kingdom, the United States, and Canada, we clarified the traits of the serotype 15A-ST63 clone. Our analysis revealed that the meropenem-resistant serotype 15A-ST63 strains from Japan originated from meropenem-susceptible strains from Japan. Recombination site prediction analysis showed that the meropenem-resistant strain-specific recombination regions included the pbp1a and pbp2b regions. A detailed analysis of the composition of these genes indicated that resistance seems to be caused by pbp1a recombination. The pbp1a gene in meropenem-resistant isolates was identical to that in multidrug (including meropenem)-resistant serotype 19A-ST320 pneumococci, which have spread in the United States. The global spread of pneumococci of this lineage is noteworthy because serotype 15A is not included in the currently used 13-valent pneumococcal conjugate vaccine.
Subject:
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Drug Resistance, Bacterial
Humans
Meropenem/pharmacology
Microbial Sensitivity Tests
Pneumococcal Infections
Research
Serogroup
Streptococcus Pneumoniae

Source:
Emerg Infect Dis. 24(2):275-283.;
Pubmed ID:
29350141
Pubmed Central ID:
PMC5782878
Document Type:
Journal Article;
Place as Subject:
Japan;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:efbc29f97c08f5837d632262f92d0efaad9a88c9ab13ee68e56aab40a5d2b48f
File Type:

Supporting Files

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