Dietary Quality and Markers of Inflammation: No Association in Youth with Type 1 Diabetes in the SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  J Diabetes Complications
• Personal Author:
  Liese, Angela D. ; Ma, Xiaonan ; Ma, Xiaoguang ; Mittleman, Murray A. ; The, Natalie S. ; Standiford, Debra A. ; Lawrence, Jean M. ; Pihoker, Catherine ; Marcovina, Santica M. ; Mayer-Davis, Elizabeth J. ; Puett, Robin C.
• Description:
  Background
  
  Systemic inflammation is a key process underlying cardiovascular disease (CVD) development, and CVD risk is significantly elevated in persons with type 1 diabetes (T1D). Youth with T1D exhibit increased levels of inflammation. Studies in persons without diabetes suggest that dietary quality influences inflammation, yet little is known about dietary influences on inflammation in youth with T1D.
  
  Methods
  
  This study evaluated the association of four distinct dietary quality indices (Dietary Approaches to Stop Hypertension (DASH), Healthy Eating Index 2010 (HEI2010), modified KIDMED and Total Antioxidant Capacity (TAC)) with biomarkers of inflammation (C-reactive protein (CRP), fibrinogen and interleukin-6 (IL-6)) in a sample of 2,520 youth with T1D participating in the SEARCH for Diabetes in Youth Study.
  
  Results
  
  Average diet quality was moderate to poor, with mean scores of 43 (DASH, range 0–80), 55 (HEI2010, range 0–100), 3.7 (mKIDMED, range 3–12) and 7237 (TAC). None of the four diet quality scores was associated with the selected biomarkers of inflammation in any analyses. Evaluation of a non-linear relationship or interactions with BMI or levels of glycemic control did not alter the findings. Replication of analyses using longitudinal data yielded consistent findings with our cross-sectional results.
  
  Conclusions
  
  Biomarkers of inflammation in youth with T1D may not be directly influenced by dietary intake, at least at the levels of dietary quality observed here. More work is needed to understand what physiologic mechanisms specific to persons with T1D might inhibit the generally beneficial influence of high dietary quality on systemic inflammation observed in populations without diabetes.
  
  
• Subjects:
  Adolescent Antioxidants Biomarkers C-Reactive Protein Child Diabetes Mellitus, Type 1 Diet Diet Surveys Feeding Behavior Female Humans Inflammation Male Nutritive Value

  More +
• Keywords:
  Diet Quality Inflammation Type 1 Diabetes Mellitus Youth
• Source:
  J Diabetes Complications. 32(2):179-184
• Pubmed ID:
  29198994
• Pubmed Central ID:
  PMC5773064
• Document Type:
  Journal Article
• Funding:
  U18DP006139/ACL/ACL HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006138/ACL/ACL HHSUnited States/ ; UL1 TR000154/TR/NCATS NIH HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006131/ACL/ACL HHSUnited States/ ; P30 DK017047/DK/NIDDK NIH HHSUnited States/ ; P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; HIR 10-001/HX/HSRD VAUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; R01 DK077949/DK/NIDDK NIH HHSUnited States/ ; U18DP006134/ACL/ACL HHSUnited States/ ; P20 GM103641/GM/NIGMS NIH HHSUnited States/ ; UL1 TR001425/TR/NCATS NIH HHSUnited States/ ; UL1 TR002319/TR/NCATS NIH HHSUnited States/ ; P2C HD041041/HD/NICHD NIH HHSUnited States/ ; P30 DK056350/DK/NIDDK NIH HHSUnited States/ ; R01 ES019168/ES/NIEHS NIH HHSUnited States/ ; UL1 TR000423/TR/NCATS NIH HHSUnited States/ ; U18DP006136/ACL/ACL HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR001450/TR/NCATS NIH HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006133/ACL/ACL HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  32
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:48a7c2f0a7eae70f0e51c2bfe9347b2e7e8ca9d7005b82181f61d609c6a69bd5
• Download URL:
  https://stacks.cdc.gov/view/cdc/51038/cdc_51038_DS1.pdf
• File Type:
  [PDF - 102.85 KB ]