Details:

• Alternative Title:
  Occup Environ Med
• Personal Author:
  Velazquez-Kronen, Raquel ; MacDonald, Leslie A. ; Akinyemiju, Tomi F. ; Cushman, Mary ; Howard, Virginia J.

  Velazquez-Kronen, Raquel ; MacDonald, Leslie A. ; Akinyemiju, Tomi F. ; Cushman, Mary ; Howard, Virginia J. Less -
• Description:
  Objectives:
  
  Work schedule demands contribute to circadian disruption and may influence health via an inflammatory response. We examined the impact of shiftwork and long work hours on inflammation in a national U.S. sample.
  
  Methods:
  
  Participants included 12,487 employed Black and White men and women aged ≥45 years enrolled in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study who completed an occupational questionnaire (2011-2013) and clinical exam (2013-2016). Cross-sectional associations between shiftwork and work hours with log-transformed high-sensitivity C-reactive protein (CRP) and white blood cell count (WBC) were examined by multiple linear regression analysis, overall and by race-sex subgroups.
  
  Results:
  
  Overall, rotating shift workers had higher log-CRP concentration compared to day workers (β = 0.09, 95% CI:0.02-0.16) and findings for WBC were null. Black women had the highest geometric mean CRP (2.82 mg/L), while White men had the highest WBC (6.35x109 cells/L). White men who worked afternoons had higher log-CRP compared to those who worked days (β=0.20, 95% CI: 0.08-0.33). Black men engaged in shiftwork <10 years working ≥55 hours/week had higher log-CRP and log-WBC compared to those working days <55 hours/week (β=0.33, 95% CI: 0.02-0.64 and β=0.10, 95% CI: 0.003-0.19). Among shift workers, non-retired White women working forward and backward shift rotations had higher log-CRP compared to those working forward only (β=0.49, 95% CI: 0.02-0.96).
  
  Conclusions:
  
  Shift workers had higher inflammatory markers compared to day workers and race-sex disparities should be examined further. These findings highlight a potential biological pathway linking work schedule demands and chronic disease.
  
  
• Subjects:
  [+]

  C-Reactive Protein Cross-Sectional Studies Female Humans Inflammation Male Regression Analysis White Work Schedule Tolerance
• Keywords:
  [+]

  C-reactive Protein Employment Leukocytes Occupations Shift Work Schedule White Blood Cells
• Source:
  Occup Environ Med. 80(11):635-643
• Pubmed ID:
  37813482
• Pubmed Central ID:
  PMC10936900
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 NS041588/NS/NINDS NIH HHSUnited States/

  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 NS041588/NS/NINDS NIH HHSUnited States/ Less -
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  [+]

  urn:sha256:e78817df4382e088141fe7e740ddae62da506904a7bb7f522e1828d045b7f243
• File Type:

• Supporting Files:
  No Additional Files