The Association of C-Reactive Protein and Physical Activity Among a Church-Based Population of African Americans

Details

• Alternative Title:
  Prev Med
• Personal Author:
  Adams, Swann Arp ; Wirth, Michael D. ; Khan, Samira ; Murphy, E. Angela ; Heiney, Sue P. ; Davis, Lisa C. ; Davis, Briana ; Drayton, Ruby F. ; Hurley, Thomas G. ; Blair, Steven M. ; Hébert, James R.
• Description:
  Objective
  
  Regular physical activity can reduce systemic inflammation and, thereby, the burden of chronic inflammatory-related conditions. This study examined whether regular physical activity, measured subjectively (Rapid Assessment of Physical Activity RAPA) and objectively (Bodymedia’s SenseWear® activity monitor SWA), is associated with inflammatory or glycemic control markers.
  
  Methods
  
  Subjects were 345 participants of the Healthy Eating and Active Living in the Spirit (HEALS) lifestyle intervention among African-American (AA) churches in South Carolina in 2009. Linear regression analyses were performed to assess the relationship between both subjectively- and objectively- measured physical activity and inflammatory markers including high sensitivity c-reactive protein (CRP), interleukin-6 (IL-6), and glycosylated hemoglobin (HbA1c).
  
  Results
  
  Those who participated in regular physical activity (RAPA) had lower CRP values compared to those who were sedentary (2.3 vs. 3.8 mg/L, p<0.01). Lower levels of CRP or IL-6 were observed among those in the highest quartile of active energy expenditure (CRP: 2.0 vs. 3.6 mg/L, p=0.01) or moderate-vigorous physical activity minutes (CRP=1.7 vs. 4.5 mg/L, p<0.01; IL-6=1.5 vs. 2.1 pg/mL, p=0.01) compared to their lowest respective quartiles as measured by the SWA.
  
  Conclusion
  
  Physical activity may improve chronic inflammation, which is a primary pathophysiological mechanism for numerous chronic disorders, especially among minority populations.
• Subjects:
  • Accelerometry
  • Adult
  • Black or African American
  • Aged
  • Biomarkers
  • C-Reactive Protein
  • Exercise
  • Female
  • Glycated Hemoglobin
  • Humans
  More +
• Keywords:
  • physical activity
  • inflammation
  • African American
  • c-reactive protein
• Source:
  Prev Med. 2015; 77:137-140
• Pubmed ID:
  26007295
• Pubmed Central ID:
  PMC4490070
• Document Type:
  Journal Article
• Funding:
  U48 DP001936/DP/NCCDPHP CDC HHSUnited States/ ; R24 MD002769/MD/NIMHD NIH HHSUnited States/ ; K01 AT007824/AT/NCCIH NIH HHSUnited States/ ; K05 CA136975/CA/NCI NIH HHSUnited States/ ; 3U48DP001936-01/DP/NCCDPHP CDC HHSUnited States/ ; R224 U54 CA153461/CA/NCI NIH HHSUnited States/ ; U54 CA153461/CA/NCI NIH HHSUnited States/
• Volume:
  77
• Download URL:
  https://stacks.cdc.gov/view/cdc/33809/cdc_33809_DS1.pdf
• File Type:
  [PDF - 183.12 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:9add0e68ceb1018203b2a132e1994dd56a547548f998ff55123a9c0e69447df91a6ed27b69b7407fae342c15d8350b134bfe965fd112f678deeb42ec5ed715c0