Sensitivity and Specificity of Suspected Case Definition Used during West Africa Ebola Epidemic

Hsu, Christopher H.; Champaloux, Steven W.; Keïta, Sakoba; Martel, Lise; Bilivogui, Pepe; Knust, Barbara; McCollum, Andrea M.

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Sensitivity and Specificity of Suspected Case Definition Used during West Africa Ebola Epidemic

Supporting Files Public Domain

Jan 2018
By Hsu, Christopher H. ; Champaloux, Steven W. ; Keïta, Sakoba ; ...

File Language:

English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Hsu, Christopher H. ; Champaloux, Steven W. ; Keïta, Sakoba ; Martel, Lise ; Bilivogui, Pepe ; Knust, Barbara ; McCollum, Andrea M.
Description:

Rapid early detection and control of Ebola virus disease (EVD) is contingent on accurate case definitions. Using an epidemic surveillance dataset from Guinea, we analyzed an EVD case definition developed by the World Health Organization (WHO) and used in Guinea. We used the surveillance dataset (March-October 2014; n = 2,847 persons) to identify patients who satisfied or did not satisfy case definition criteria. Laboratory confirmation determined cases from noncases, and we calculated sensitivity, specificity and predictive values. The sensitivity of the defintion was 68.9%, and the specificity of the definition was 49.6%. The presence of epidemiologic risk factors (i.e., recent contact with a known or suspected EVD case-patient) had the highest sensitivity (74.7%), and unexplained deaths had the highest specificity (92.8%). Results for case definition analyses were statistically significant (p<0.05 by χ2 test). Multiple components of the EVD case definition used in Guinea contributed to improved overall sensitivity and specificity.
Subjects:

Adolescent Adult Child Child, Preschool Epidemics Female Hemorrhagic Fever, Ebola Humans Infant Male Middle Aged Sensitivity And Specificity Young Adult
Source:

Emerg Infect Dis. 24(1):9-14.
Pubmed ID:

29260687
Pubmed Central ID:

PMC5749454
Document Type:

Journal Article
Name as Subject:

World Health Organization
Place as Subject:

Africa, Western ; Guinea
Volume:

24
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:6a3b9a7295800b9de8757da36d6be92fb2185012c4d6afcc90bea2b6d7f09b4c
Download URL:

https://stacks.cdc.gov/view/cdc/50928/cdc_50928_DS1.pdf
File Type:

[PDF - 408.86 KB ]

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File Language:

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