Details:

Alternative Title:
Viral Immunol
Personal Author:
Amoah, Samuel ; Cao, Weiping ; Ranjan, Priya ; Greer, Patricia ; Shieh, Wun-Ju ; ... More +
Amoah, Samuel ; Cao, Weiping ; Ranjan, Priya ; Greer, Patricia ; Shieh, Wun-Ju ; Zaki, Sherif R. ; Katz, Jacqueline M. ; Sambhara, Suryaprakash ; Gangappa, Shivaprakash ; Less -
Description:
Influenza viruses are pathogens of significant public health importance. The influence of nutritional status on severity of disease has become increasingly recognized. In particular, high dietary salt intake has been linked to cardiovascular disease, but the effects on infectious diseases have not been studied. This study investigated the impact on influenza-induced morbidity and mortality in mice fed isocaloric diets containing 10-fold increments of sodium by altering the salt levels. Following infection, despite higher levels of IFN-gamma cytokine in the lung as well as virus-neutralizing antibody in the serum of mice fed the lowest salt level, the amounts of dietary salt intake had no substantial impact on the disease severity or the ability to respond immunologically to the infection.
Subject:
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Animals
Antibodies, Neutralizing
Antibodies, Viral
Article
Diet
Disease Models, Animal
Female
Influenza A Virus
Interferon-gamma
Lung
Mice
Mice, Inbred C57BL
Orthomyxoviridae Infections
Salts
Severity Of Illness Index
Survival Analysis

Source:
Viral Immunol. 28(9):532-537 ;
Pubmed ID:
26284685
Pubmed Central ID:
PMC5737935
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:58d5c6542d0ea98d18348f26380a9b9db1428826bc5ba32be4bdfdb2fbaee9c7
File Type:

Supporting Files

• 	NIHMS927035-supplement-Suppl_Fig-1.tif	tiff
  	NIHMS927035-supplement-Suppl_Table-2.docx	docx
  	NIHMS927035-supplement-Suppl__Table-1.docx	docx
  	nihms927035.nxml	xml
  	nihms927035f1.gif	gif
  	nihms927035f1.jpg	jpeg
  	nihms927035f2.gif	gif
  	nihms927035f2.jpg	jpeg

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