Increased Dietary Salt Intake Does Not Influence Influenza A Virus–Induced Disease Severity in Mice

Amoah, Samuel; Cao, Weiping; Ranjan, Priya; Greer, Patricia; Shieh, Wun-Ju; Zaki, Sherif R.; Katz, Jacqueline M.; Sambhara, Suryaprakash; Gangappa, Shivaprakash

doi:10.1089/vim.2015.0037

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Increased Dietary Salt Intake Does Not Influence Influenza A Virus–Induced Disease Severity in Mice

Published Date:

Aug 18 2015

Publisher's site:

http://dx.doi.org/10.1089/vim.2015.0037 New Site Icon

Source:

Viral Immunol. 28(9):532-537.

[PDF-837.98 KB]

Details:

Personal Authors:

Amoah, Samuel ; Cao, Weiping ; Ranjan, Priya ; Greer, Patricia ; Shieh, Wun-Ju ; ... More ▼

Keywords:

[+]

Pubmed ID:

26284685

Pubmed Central ID:

PMC5737935

Description:

Influenza viruses are pathogens of significant public health importance. The influence of nutritional status on severity of disease has become increasingly recognized. In particular, high dietary salt intake has been linked to cardiovascular disease, but the effects on infectious diseases have not been studied. This study investigated the impact on influenza-induced morbidity and mortality in mice fed isocaloric diets containing 10-fold increments of sodium by altering the salt levels. Following infection, despite higher levels of IFN-gamma cytokine in the lung as well as virus-neutralizing antibody in the serum of mice fed the lowest salt level, the amounts of dietary salt intake had no substantial impact on the disease severity or the ability to respond immunologically to the infection.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Main Document Checksum:

[+]

Supporting Files:

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