Welcome to CDC stacks | Prophylaxis use among males with haemophilia B in the United States - 50516 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Prophylaxis use among males with haemophilia B in the United States
  • Published Date:
    Aug 06 2017
  • Source:
    Haemophilia. 23(6):910-917.
  • Language:
    English
Filetype[PDF-229.97 KB]


Details:
  • Pubmed ID:
    28780772
  • Pubmed Central ID:
    PMC5724962
  • Description:
    Introduction

    Prophylaxis is considered the optimal treatment for persons with moderate to severe haemophilia (factor activity between 1–5% of normal and <1% of normal respectively) in countries where safe factor concentrates are available and economically feasible. Historically, prophylactic treatment has not been well studied in the haemophilia B (HB) population due to difficulties in obtaining a sufficiently large sample.

    Aim

    This study examines the prevalence of prophylaxis use among a robust sample of persons with HB in the United States and its association with specific demographic and clinical characteristics.

    Methods

    Using data collected between 1998 and 2011 for the Centers for Disease Control and Prevention’s Universal Data Collection project, we analysed data on 2428 males with moderate to severe HB aged 2–79 years who were seen at 135 federally funded haemophilia treatment centres.

    Results

    Prevalence of prophylactic treatment in our sample was 35% among children and youth (ages 2–19) and 14% among adults (age 20 and older). Increased HB prophylaxis use was significantly associated with younger age (<40 years), Hispanic ethnicity, severe disease and self-infusion, while decreased use was associated with above-normal body mass index (BMI) in adults. Health care coverage was vital, although type of coverage did not appear to influence access.

    Conclusions

    Our analysis confirms previous reports of lower prevalence of prophylaxis use among individuals with HB compared to those with haemophilia A and adds to the body of knowledge regarding treatment patterns among a historically understudied population.

  • Document Type:
  • Collection(s):
  • Main Document Checksum:
No Related Documents.
You May Also Like: