Details:

Alternative Title:
Epidemiology
Personal Author:
Pennington, Audrey Flak ; Strickland, Matthew J. ; Klein, Mitchel ; Zhai, Xinxin ; Bates, Josephine T. ; ... More +
Pennington, Audrey Flak ; Strickland, Matthew J. ; Klein, Mitchel ; Zhai, Xinxin ; Bates, Josephine T. ; Drews-Botsch, Carolyn ; Hansen, Craig ; Russell, Armistead G. ; Tolbert, Paige E. ; Darrow, Lyndsey A. Less -
Description:
Background

Early-life exposure to traffic-related air pollution exacerbates childhood asthma, but it is unclear what role it plays in asthma development.

Methods

The association between exposure to primary mobile source pollutants during pregnancy and during infancy and asthma incidence by ages 2 through 6 was examined in the Kaiser Air Pollution and Pediatric Asthma Study, a racially diverse birth cohort of 24,608 children born between 2000 and 2010 and insured by Kaiser Permanente Georgia. We estimated concentrations of mobile source fine particulate matter (PM2.5, μg/m3), nitrogen oxides (NOX, ppb), and carbon monoxide (CO, ppm) at the maternal and child residence using a Research LINE-source dispersion model for near-surface releases. Asthma was defined using diagnoses and medication dispensings from medical records. We used binomial generalized linear regression to model the impact of exposure continuously and by quintiles on asthma risk.

Results

Controlling for covariates and modeling log-transformed exposure, a 2.7-fold increase in first year of life PM2.5 was associated with an absolute 4.1% (95% CI 1.6%, 6.6%) increase in risk of asthma by age 5. Quintile analysis showed an increase in risk from the first to second quintile, but similar risk across quintiles 2–5. Risk differences increased with follow-up age. Results were similar for NOX and CO and for exposure during pregnancy and the first year of life due to high correlation.

Conclusions

Results provide limited evidence for an association of early-life mobile source air pollution with childhood asthma incidence with a steeper concentration–response relationship observed at lower levels of exposure.


Subjects:
[+]
Air Pollutants Air Pollution Asthma Carbon Monoxide Child Child, Preschool Cohort Studies Environmental Exposure Female Humans Incidence Infant Linear Models Male Nitrogen Oxides Particulate Matter Pregnancy Prenatal Exposure Delayed Effects Proportional Hazards Models Retrospective Studies Vehicle Emissions
Source:
Epidemiology. 29(1):22-30
Pubmed ID:
28926373
Pubmed Central ID:
PMC5718963
Document Type:
Journal Article
Funding:
R03 HD084884/HD/NICHD NIH HHS/United States ; T03 OH008609/OH/NIOSH CDC HHS/United States ; T32 HD052460/HD/NICHD NIH HHS/United States
R03 HD084884/HD/NICHD NIH HHS/United States ; T03 OH008609/OH/NIOSH CDC HHS/United States ; T32 HD052460/HD/NICHD NIH HHS/United States Less -
Place as Subject:
Georgia
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c1188c7802fa2dedbd7e6b87e38efb87671c7aa39ecfdc8df2c09a4a41b30f1b
Download URL:
https://stacks.cdc.gov/view/cdc/50491/cdc_50491_DS1.pdf
File Type:

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