High Rate of MCR-1–Producing Escherichia coli and Klebsiella pneumoniae among Pigs, Portugal

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Kieffer, Nicolas ; Aires-de-Sousa, Marta ; Nordmann, Patrice ; Poirel, Laurent
• Description:
  The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1-producing isolates. Most isolates corresponded to nonclonally related E. coli belonging to many sequence types; we also found 2 Klebsiella pneumoniae sequence types. The mcr-1 gene was carried on IncHI2 or IncP plasmid backbones. Our finding of a high rate of MCR-1 producers on 2 pig farms in Portugal highlights the diffusion of that colistin-resistance determinant at the farm level. The fact that the pigs received colistin as metaphylaxis in their feed during the 6 weeks before sampling suggests selective pressure.
• Subjects:
  Antimicrobial Resistance Bacteria Colistin Escherichia Coli High Rate Of MCR-1–Producing Escherichia Coli And Klebsiella Pneumoniae Among Pigs, Portugal Klebsiella Pneumonia MCR-1 Mcr-1 Gene Pigs Portugal Research

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• Source:
  Emerg Infect Dis. 23(12):2023-2029.
• Pubmed ID:
  29148380
• Pubmed Central ID:
  PMC5708242
• Document Type:
  Journal Article
• Volume:
  23
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:913a587343565adda4e596337c7fe7d1c4ce0076ebc3ab57d433dfcb068eeb91
• Download URL:
  https://stacks.cdc.gov/view/cdc/50198/cdc_50198_DS1.pdf
• File Type:
  [PDF - 771.74 KB ]