Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Kieffer, Nicolas ; Aires-de-Sousa, Marta ; Nordmann, Patrice ; Poirel, Laurent
Kieffer, Nicolas ; Aires-de-Sousa, Marta ; Nordmann, Patrice ; Poirel, Laurent Less -
Description:
The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1-producing isolates. Most isolates corresponded to nonclonally related E. coli belonging to many sequence types; we also found 2 Klebsiella pneumoniae sequence types. The mcr-1 gene was carried on IncHI2 or IncP plasmid backbones. Our finding of a high rate of MCR-1 producers on 2 pig farms in Portugal highlights the diffusion of that colistin-resistance determinant at the farm level. The fact that the pigs received colistin as metaphylaxis in their feed during the 6 weeks before sampling suggests selective pressure.
Subject:
[+]
Antimicrobial Resistance
Bacteria
Colistin
Escherichia Coli
High Rate Of MCR-1–Producing Escherichia Coli And Klebsiella Pneumoniae Among Pigs, Portugal
Klebsiella Pneumonia
MCR-1
Mcr-1 Gene
Pigs
Portugal
Research

Source:
Emerg Infect Dis. 23(12):2023-2029.
Pubmed ID:
29148380
Pubmed Central ID:
PMC5708242
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:913a587343565adda4e596337c7fe7d1c4ce0076ebc3ab57d433dfcb068eeb91
File Type:

Supporting Files

• 	17-0883-F.gif	gif
  	17-0883-F.jpg	jpeg
  	17-0883.nxml	xml

More +