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Urinary and Blood Cadmium and Lead and Kidney Function: NHANES 2007–2012

Supporting Files
File Language:
English


Details

  • Alternative Title:
    Int J Hyg Environ Health
  • Personal Author:
  • Description:
    Background

    Cadmium (Cd) and lead (Pb) are widespread environmental contaminants that are known nephrotoxins. However, their nephrotoxic effects at low-environmental exposure levels are debated.

    Objective

    We examined the association of blood Pb (B-Pb), blood Cd (B-Cd), urinary Pb (U-Pb) and urinary Cd (U-Cd) with estimated glomerular filtration rate (eGFR) and urinary albumin (ALB).

    Methods

    We used multivariate linear regression to analyze the association between B-Pb, B-Cd, U-Pb, and U-Cd with eGFR and ALB in adult participants (≥20 years of age) in NHANES 2007–2012. The dataset was limited to NHANES individuals with both blood and urinary metal measurements.

    Results

    We found a statistically significant inverse association between eGFR and B-Cd and statistically significant positive associations between eGFR and both U-Cd and U-Pb, as well as statistically significant associations between ALB and the 3rd and 4th quartiles of U-Cd.

    Conclusions

    The inverse association between eGFR and B-Cd, in conjunction with positive associations between eGFR and ALB with U-Cd, suggest that U-Cd measurement at low levels of exposure may result from changes in renal excretion of Cd due to kidney function and protein excretion. However, renal effects such as hyperfiltration from Cd-mediated kidney damage or creatinine-specific Cd effects cannot be excluded with this cross-sectional design.

  • Subjects:
  • Source:
    Int J Hyg Environ Health. 219(3):261-267.
  • Pubmed ID:
    26852280
  • Pubmed Central ID:
    PMC5685486
  • Document Type:
    Journal Article
  • Funding:
    CC999999/Intramural CDC HHS/United States
  • Place as Subject:
    United States
  • Volume:
    219
  • Issue:
    3
  • Collection(s):
  • Main Document Checksum:
    urn:sha256:d6a8adfb5ac925a2467c3e845350218fe852b390e8252329fdce857b371ec411
  • Download URL:
  • File Type:
    Filetype[PDF - 342.34 KB ]
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