Details:

Alternative Title:
Int J Neonatal Screen
Publisher's site:
http://dx.doi.org/10.3390/ijns1020069
Personal Author:
Hall, Elizabeth M. ; Flores, Sharon R. ; De Jesús, Víctor R.
Hall, Elizabeth M. ; Flores, Sharon R. ; De Jesús, Víctor R. Less -
Description:
Dried blood spots (DBS) have been used in newborn screening (NBS) tests for over 50 years. The Newborn Screening Quality Assurance Program (NSQAP) at the Centers for Disease Control and Prevention (CDC) conducted studies to assess the individual impacts of hematocrit and total-spot volume on characteristics of DBS samples. Per-punch serum volumes decreased 27%, RBC volumes more than doubled, absorption times increased over 300%, and spot diameters decreased marginally between the hematocrits of 40% to 65%. Per-punch serum and RBC volumes decreased logarithmically with lowering total-spot volumes. Patient hematocrit is an uncontrollable variable and inevitably affects the resulting punch from a DBS sample. It may be possible, though, to identify samples that fall outside of an acceptable range by noting certain physical characteristics of the DBS.
Subject:
[+]
Article
Dried Blood Spots
Filter Paper
Hematocrit
Newborn Screening
Specimen Collection Device

Source:
Int J Neonatal Screen. 1(2):69-78.
Pubmed ID:
28868497
Pubmed Central ID:
PMC5580822
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:21899745b4b0c68010fe8441ac27b10b66ded7c757e5fd81e289af7b01e758cf
File Type:

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