Details:

Alternative Title:
Enliven J Stem Cell Res Regen Med
Personal Author:
Qin, Yunlong ; Hutson, Christina ; Wu, Xianfu ; Xu, Jingyao ; Carroll, Darin
Qin, Yunlong ; Hutson, Christina ; Wu, Xianfu ; Xu, Jingyao ; Carroll, Darin Less -
Description:
Cancer immunosurveillance is an important host protection process, monitoring the presence of irregular cells that could potentially transform into tumor cells, effectively clearing the body of transformed tumor cells at their earliest stages, and thus maintaining regular cellular homeostasis. Natural killer (NK) cells are effector lymphocytes of the innate immune system, playing a critical role in surveillance for tumor cells, while also eliminating virally infected cells. The significance of the anti-tumor role of NK cells was recently further verified by findings that immunosuppression in most cancer patients is not perceptible until late stages. NK cells express the low-affinity Fc-activating receptor, CD16, and the inhibitory receptor, killer cell immunoglobulin-like receptor (KIR). Consequently, activation of NK cells is determined by the balance of inhibitory and activating receptor stimulation. Here, we propose establishing an induced pluripotent stem cell (iPSC)-derived NK cell line with KIR gene knockout or knockdown as a possible regimen to treat and prevent cancer. We further postulate that an optimal mixture of NK iPSCs with and without KIR gene knockout, would reach a maximum antitumor activity, with minimal side effects. We also discuss the possible advantages of KIR-knockout NK iPSCs for adoptive immunotherapy in patients with cancer.
Subjects:
[+]
Article Immunosurveillance Induced Pluripotent Stem Cells Killer Cell Immunoglobulin-like Receptor Natural Killer Cell
Source:
Enliven J Stem Cell Res Regen Med. 3(1).
Pubmed ID:
28845462
Pubmed Central ID:
PMC5568640
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ca14315b98dbb3e2235d095b0d314fc583be16c7bf4afb470e6b6ec8b98035db
Download URL:
https://stacks.cdc.gov/view/cdc/48179/cdc_48179_DS1.pdf
File Type:

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