Emergence of Plasmid-Mediated Fosfomycin-Resistance Genes among Escherichia coli Isolates, France

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Benzerara, Yahia ; Gallah, Salah ; Hommeril, Baptiste ; Genel, Nathalie ; Decré, Dominique ; Rottman, Martin ; Arlet, Guillaume
• Description:
  FosA, a glutathione S-transferase that inactivates fosfomycin, has been reported as the cause of enzymatic resistance to fosfomycin. We show that multiple lineages of FosA-producing extended spectrum β-lactamase Escherichia coli have circulated in France since 2012, potentially reducing the efficacy of fosfomycin in treating infections with antimicrobial drug-resistant gram-negative bacilli.
• Subjects:
  Anti-Bacterial Agents Beta-Lactamases Drug Resistance, Multiple, Bacterial Escherichia Coli Escherichia Coli Infections Foscarnet Fosfomycin Gene Expression Humans Isoenzymes Microbial Sensitivity Tests Plasmids Prevalence

  More +
• Source:
  Emerg Infect Dis. 23(9):1564-1567.
• Pubmed ID:
  28820368
• Pubmed Central ID:
  PMC5572872
• Document Type:
  Journal Article
• Name as Subject:
  France ; France
• Volume:
  23
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6554a308f309fb7a8d0503640ff1f14c92a76c8b42b247fbb58bf2f63273d707
• Download URL:
  https://stacks.cdc.gov/view/cdc/47976/cdc_47976_DS1.pdf
• File Type:
  [PDF - 888.43 KB ]