Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Whiley, David M. ; Trembizki, Ella ; Buckley, Cameron ; Freeman, Kevin ; Baird, Robert W. ; ... More +
Whiley, David M. ; Trembizki, Ella ; Buckley, Cameron ; Freeman, Kevin ; Baird, Robert W. ; Beaman, Miles ; Chen, Marcus ; Donovan, Basil ; Kundu, Ratan L. ; Fairley, Christopher K. ; Guy, Rebecca ; Hogan, Tiffany ; Kaldor, John M. ; Karimi, Mahdad ; Limnios, Athena ; Regan, David G. ; Ryder, Nathan ; Su, Jiunn-Yih ; Ward, James ; Lahra, Monica M. Less -
Description:
Neisseria gonorrhoeae antimicrobial resistance (AMR) is a globally recognized health threat; new strategies are needed to enhance AMR surveillance. The Northern Territory of Australia is unique in that 2 different first-line therapies, based primarily on geographic location, are used for gonorrhea treatment. We tested 1,629 N. gonorrhoeae nucleic acid amplification test-positive clinical samples, collected from regions where ceftriaxone plus azithromycin or amoxicillin plus azithromycin are recommended first-line treatments, by using 8 N. gonorrhoeae AMR PCR assays. We compared results with those from routine culture-based surveillance data. PCR data confirmed an absence of ceftriaxone resistance and a low level of azithromycin resistance (0.2%), and that penicillin resistance was <5% in amoxicillin plus azithromycin regions. Rates of ciprofloxacin resistance and penicillinase-producing N. gonorrhoeae were lower when molecular methods were used. Molecular methods to detect N. gonorrhoeae AMR can increase the evidence base for treatment guidelines, particularly in settings where culture-based surveillance is limited.
Subject:
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AMR
Antimicrobial Drugs
Antimicrobial Resistance
Australia
Bacteria
Culture
Gonococcus
Gonorrhea
Molecular
Molecular Antimicrobial Resistance Surveillance For Neisseria Gonorrhoeae, Northern Territory, Australia
Neisseria Gonorrhoeae
Northern Territory
Research
Surveillance

Source:
Emerg Infect Dis. 23(9):1478-1485.
Pubmed ID:
28820128
Pubmed Central ID:
PMC5572890
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:e248707420c0b63f5fbf5ccc2368abba01e4e3967644d5784baa15e2d24a06c2
File Type:

Supporting Files

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