Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Whiley, David M. ; Trembizki, Ella ; Buckley, Cameron ; Freeman, Kevin ; Baird, Robert W. ; Beaman, Miles ; Chen, Marcus ; Donovan, Basil ; Kundu, Ratan L. ; Fairley, Christopher K. ; Guy, Rebecca ; Hogan, Tiffany ; Kaldor, John M. ; Karimi, Mahdad ; Limnios, Athena ; Regan, David G. ; Ryder, Nathan ; Su, Jiunn-Yih ; Ward, James ; Lahra, Monica M.
• Description:
  Neisseria gonorrhoeae antimicrobial resistance (AMR) is a globally recognized health threat; new strategies are needed to enhance AMR surveillance. The Northern Territory of Australia is unique in that 2 different first-line therapies, based primarily on geographic location, are used for gonorrhea treatment. We tested 1,629 N. gonorrhoeae nucleic acid amplification test-positive clinical samples, collected from regions where ceftriaxone plus azithromycin or amoxicillin plus azithromycin are recommended first-line treatments, by using 8 N. gonorrhoeae AMR PCR assays. We compared results with those from routine culture-based surveillance data. PCR data confirmed an absence of ceftriaxone resistance and a low level of azithromycin resistance (0.2%), and that penicillin resistance was <5% in amoxicillin plus azithromycin regions. Rates of ciprofloxacin resistance and penicillinase-producing N. gonorrhoeae were lower when molecular methods were used. Molecular methods to detect N. gonorrhoeae AMR can increase the evidence base for treatment guidelines, particularly in settings where culture-based surveillance is limited.
• Subjects:
  AMR Antimicrobial Drugs Antimicrobial Resistance Australia Bacteria Culture Gonococcus Gonorrhea Molecular Molecular Antimicrobial Resistance Surveillance For Neisseria Gonorrhoeae, Northern Territory, Australia Neisseria Gonorrhoeae Northern Territory Research Surveillance

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• Source:
  Emerg Infect Dis. 23(9):1478-1485.
• Pubmed ID:
  28820128
• Pubmed Central ID:
  PMC5572890
• Document Type:
  Journal Article
• Volume:
  23
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e248707420c0b63f5fbf5ccc2368abba01e4e3967644d5784baa15e2d24a06c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/47973/cdc_47973_DS1.pdf
• File Type:
  [PDF - 1.56 MB ]