Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia

Whiley, David M.; Trembizki, Ella; Buckley, Cameron; Freeman, Kevin; Baird, Robert W.; Beaman, Miles; Chen, Marcus; Donovan, Basil; Kundu, Ratan L.; Fairley, Christopher K.; Guy, Rebecca; Hogan, Tiffany; Kaldor, John M.; Karimi, Mahdad; Limnios, Athena; Regan, David G.; Ryder, Nathan; Su, Jiunn-Yih; Ward, James; Lahra, Monica M.

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Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia

Published Date:

Sep 2017

Source:

Emerg Infect Dis. 23(9):1478-1485.

[PDF-1.56 MB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Whiley, David M. ; Trembizki, Ella ; Buckley, Cameron ; Freeman, Kevin ; Baird, Robert W. ; ... More ▼

Description:

Neisseria gonorrhoeae antimicrobial resistance (AMR) is a globally recognized health threat; new strategies are needed to enhance AMR surveillance. The Northern Territory of Australia is unique in that 2 different first-line therapies, based primarily on geographic location, are used for gonorrhea treatment. We tested 1,629 N. gonorrhoeae nucleic acid amplification test-positive clinical samples, collected from regions where ceftriaxone plus azithromycin or amoxicillin plus azithromycin are recommended first-line treatments, by using 8 N. gonorrhoeae AMR PCR assays. We compared results with those from routine culture-based surveillance data. PCR data confirmed an absence of ceftriaxone resistance and a low level of azithromycin resistance (0.2%), and that penicillin resistance was <5% in amoxicillin plus azithromycin regions. Rates of ciprofloxacin resistance and penicillinase-producing N. gonorrhoeae were lower when molecular methods were used. Molecular methods to detect N. gonorrhoeae AMR can increase the evidence base for treatment guidelines, particularly in settings where culture-based surveillance is limited.

Subject:

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Pubmed ID:

28820128

Pubmed Central ID:

PMC5572890

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia

Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia

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