Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Patel, Chirag J. ; Kerr, Jacqueline ; Thomas, Duncan C. ; Mukherjee, Bhramar ; Ritz, Beate ; Chatterjee, Nilanjan ; Jankowska, Marta ; Madan, Juliette ; Karagas, Margaret R. ; McAllister, Kimberly A. ; Mechanic, Leah E. ; Fallin, M. Daniele ; Ladd-Acosta, Christine ; Blair, Ian A. ; Teitelbaum, Susan L. ; Amos, Christopher I.
• Description:
  Background
  
  A growing number and increasing diversity of factors are available for epidemiological studies. These measures provide new avenues for discovery and prevention yet they also raise many challenges for adoption in epidemiological investigations.
  
  Methods
  
  We evaluate 1) designs to investigate diseases that consider heterogeneous and multi-dimensional indicators of exposure and behavior, 2) the implementation of numerous methods to capture indicators of exposure, and 3) the analytical methods required for discovery and validation.
  
  Results
  
  Case-control studies have provided insights into genetic susceptibility but are insufficient for characterizing complex effects of environmental factors on disease development. Prospective designs are required but must balance extended data collection with follow-up of study participants. Two phase designs are described. We discuss innovations in assessments including the microbiome, mass spectrometry and metabolomics, behavioral assessment, dietary, physical activity and occupational exposure assessment, air pollution monitoring and global positioning and individual sensors. The availability of extensive correlated data raises new challenges in disentangling specific exposures that influence cancer risk from among extensive and often correlated exposures.
  
  Conclusions
  
  New exposure assessments offer many new opportunities for environmental assessment in cancer development.
  
  Impact
  
  We describe and evaluate the state of the art for evaluating high dimensional environmental studies.
  
  
• Keywords:
  Environmental Exposure Female Humans Male Microbiota Occupational Exposure Risk Assessment
• Source:
  Cancer Epidemiol Biomarkers Prev. 26(9):1370-1380
• Pubmed ID:
  28710076
• Pubmed Central ID:
  PMC5581729
• Document Type:
  Journal Article
• Funding:
  U24 OD023382/OD/NIH HHSUnited States/ ; P30 ES007048/ES/NIEHS NIH HHSUnited States/ ; R01 CA186566/CA/NCI NIH HHSUnited States/ ; U19 CA203654/CA/NCI NIH HHSUnited States/ ; U01 DD000746/DD/NCBDD CDC HHSUnited States/ ; R00 ES023504/ES/NIEHS NIH HHSUnited States/ ; AS7659/AS/Autism SpeaksUnited States/ ; R21 ES025052/ES/NIEHS NIH HHSUnited States/ ; R01 CA095586/CA/NCI NIH HHSUnited States/ ; P30 ES013508/ES/NIEHS NIH HHSUnited States/ ; R01 ES015211/ES/NIEHS NIH HHSUnited States/ ; UG3 OD023275/OD/NIH HHSUnited States/ ; P01 CA196569/CA/NCI NIH HHSUnited States/ ; U10 DD000183/DD/NCBDD CDC HHSUnited States/ ; P20 GM104416/GM/NIGMS NIH HHSUnited States/ ; U19 CA148127/CA/NCI NIH HHSUnited States/ ; P20 GM103534/GM/NIGMS NIH HHSUnited States/ ; U2C ES026555/ES/NIEHS NIH HHSUnited States/ ; R01 ES025216/ES/NIEHS NIH HHSUnited States/ ; R01 AI127250/AI/NIAID NIH HHSUnited States/ ; P30 CA023108/CA/NCI NIH HHSUnited States/ ; R01 AG042187/AG/NIA NIH HHSUnited States/ ; P20 ES018175/ES/NIEHS NIH HHSUnited States/ ; P42 ES023720/ES/NIEHS NIH HHSUnited States/ ; R21 CA191651/CA/NCI NIH HHSUnited States/ ; P01 ES022832/ES/NIEHS NIH HHSUnited States/ ; P30 CA016520/CA/NCI NIH HHSUnited States/ ; U01 DD001214/DD/NCBDD CDC HHSUnited States/ ; U01 CA196386/CA/NCI NIH HHSUnited States/ ; R01 ES025531/ES/NIEHS NIH HHSUnited States/ ; R01 CA091016/CA/NCI NIH HHSUnited States/ ; R21 ES025573/ES/NIEHS NIH HHSUnited States/
• Volume:
  26
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:dab564a883fbceb4e983239e03bd09a30da6558ad5a68b5c00a51e3c7cb87652
• Download URL:
  https://stacks.cdc.gov/view/cdc/47891/cdc_47891_DS1.pdf
• File Type:
  [PDF - 114.52 KB ]