Dermal Exposure and Absorption of Chemicals

Details

• Personal Author:
  Bunge AL ; Frasch ; Kasting GB ; Kissel JC
• Description:
  Functions of the skin include, but are not limited to, physical protection of internal tissues, bones, and organs; sensing of the external environment; regulation of body temperature; and regulation of water content. Regulation of water transport depends upon the skin functioning as a semipermeable membrane. As such, it can also absorb chemicals other than water from (or emit other chemicals to) the external environment. Evaluation of potential chemical transfer into the skin or into the body via the skin is an essential component of exposure and hazard assessment in the context of risk assessment and is thus a critical element of environmental and occupational health practice. The skin is a potential barrier to systemic absorption, but can also be the target organ. This chapter deals primarily with the former, but the two phenomena cannot be entirely isolated as skin toxicity requires at least partial penetration and skin damage can reduce the barrier property of skin. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Hazardous Substances Occupational Exposure Occupational Health Risk Assessment Safety Skin Skin Absorption Toxicology
• Keywords:
  Biological Function Chemical Hazards Chemicals Dermal Absorption Environmental Exposure Exposure Assessment Hazard Recognition In Vitro Studies In Vivo Studies Mathematical Models Occupational Exposure Physiology Risk Assessment Risk Management Skin Absorption Skin Exposure

  More +
• ISBN:
  9780081006016
• Publisher:
  Elsevier
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Colorado ; Ohio ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 8 ; Washington ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  112-127
• Volume:
  1
• NIOSHTIC Number:
  nn:20051532
• Citation:
  Comprehensive toxicology, third edition. McQueen CA, ed. Oxford, UK: Elsevier, 2017 Dec; 1:112-127
• Contact Point Address:
  J C Kissel, University of Washington, Seattle, WA, United States
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Beryllium (CAS RN 7440-41-7) ; Quartz (SiO2) (CAS RN 14808-60-7)
• Editor(s):
  McQueen CA
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Oil and Gas Extraction
• Peer Reviewed:
  False
• Source Full Name:
  Comprehensive toxicology, third edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6de349fa2842dfd0bdc521979a93583bd2af3eb40752a6a0b7001d6f3b5507e7f11d44d178bcaa5216ad7b5a41ce2d5d9ec3a97db0eb474db3bff3b7fe9e4be0
• Download URL:
  https://stacks.cdc.gov/view/cdc/211436/cdc_211436_DS1.pdf
• File Type:
  [PDF - 1.19 MB ]