Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Reisler, Ronald B. ; Yu, Chenggang ; Donofrio, Michael J. ; Warren, Travis K. ; Wells, Jay B. ; ... More +
Reisler, Ronald B. ; Yu, Chenggang ; Donofrio, Michael J. ; Warren, Travis K. ; Wells, Jay B. ; Stuthman, Kelly S. ; Garza, Nicole L. ; Vantongeren, Sean A. ; Donnelly, Ginger C. ; Kane, Christopher D. ; Kortepeter, Mark G. ; Bavari, Sina ; Cardile, Anthony P. Less -
Description:
The Ebola virus (EBOV) outbreak in West Africa during 2013-2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models. Furthermore, the data support that, in nonhuman primates, the Makona strain of EBOV may be less virulent than the Kikwit strain of EBOV. The applicability of these findings as potential diagnostic and management tools for EVD in humans warrants further investigation.
Subject:
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Cynomolgus Macaques
Early Indicators Of Infection
Ebolavirus
Hemorrhagic Fever, Ebola
Kikwit Strain
Macaca Fascicularis
Macaca Mulatta
Makona Strain
Monkeys
Nonhuman Primate Models
Research
Rhesus Macaques
Survival
Viruses
Zoonoses

Source:
Emerg Infect Dis. 23(8):1316-1324.
Pubmed ID:
28726603
Pubmed Central ID:
PMC5547776
Document Type:
Journal Article
Place as Subject:
Maryland
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:4c259c2fda5b6a117f0d59eff6efdc8e15753ada1e24f4a83091032929993848
File Type:

Supporting Files

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