Characterization of Fitzroy River Virus and Serologic Evidence of Human and Animal Infection

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Johansen, Cheryl A. ; Williams, Simon H. ; Melville, Lorna F. ; Nicholson, Jay ; Hall, Roy A. ; Bielefeldt-Ohmann, Helle ; Prow, Natalie A. ; Chidlow, Glenys R. ; Wong, Shani ; Sinha, Rohini ; Williams, David T. ; Lipkin, W. Ian ; Smith, David W.
• Description:
  In northern Western Australia in 2011 and 2012, surveillance detected a novel arbovirus in mosquitoes. Genetic and phenotypic analyses confirmed that the new flavivirus, named Fitzroy River virus, is related to Sepik virus and Wesselsbron virus, in the yellow fever virus group. Most (81%) isolates came from Aedes normanensis mosquitoes, providing circumstantial evidence of the probable vector. In cell culture, Fitzroy River virus replicated in mosquito (C6/36), mammalian (Vero, PSEK, and BSR), and avian (DF-1) cells. It also infected intraperitoneally inoculated weanling mice and caused mild clinical disease in 3 intracranially inoculated mice. Specific neutralizing antibodies were detected in sentinel horses (12.6%), cattle (6.6%), and chickens (0.5%) in the Northern Territory of Australia and in a subset of humans (0.8%) from northern Western Australia.
• Subjects:
  Aedes Animals Antibodies, Monoclonal Antibodies, Viral Flavivirus Flavivirus Infections Genome, Viral Humans Mice Phylogeny Recombination, Genetic Research Virulence Virus Replication Whole Genome Sequencing

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• Source:
  Emerg Infect Dis. 23(8):1289-1299.
• Pubmed ID:
  28726621
• Pubmed Central ID:
  PMC5547785
• Document Type:
  Journal Article
• Place as Subject:
  Australia ; United States
• Location:
  Oceania ; North America
• Volume:
  23
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:920fd540392c2f643015f2d6c85a84ea6f5c97fadf0b78ba58d73248c1c991fa
• Download URL:
  https://stacks.cdc.gov/view/cdc/47386/cdc_47386_DS1.pdf
• File Type:
  [PDF - 2.15 MB ]