Maguari Virus Associated with Human Disease

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Groseth, Allison ; Vine, Veronica ; Weisend, Carla ; Guevara, Carolina ; Watts, Douglas ; Russell, Brandy ; Tesh, Robert B. ; Ebihara, Hideki
• Description:
  Despite the lack of evidence for symptomatic human infection with Maguari virus (MAGV), its close relation to Cache Valley virus (CVV), which does infect humans, remains a concern. We sequenced the complete genome of a MAGV-like isolate (OBS6657) obtained from a febrile patient in Pucallpa, Ucayali, Peru, in 1998. To facilitate its classification, we generated additional full-length sequences for the MAGV prototype strain, 3 additional MAGV-like isolates, and the closely related CVV (7 strains), Tlacotalpan (1 strain), Playas (3 strains), and Fort Sherman (1 strain) viruses. The OBS6657 isolate is similar to the MAGV prototype, whereas 2 of the other MAGV-like isolates are located on a distinct branch and most likely warrant classification as a separate virus species and 1 is, in fact, a misclassified CVV strain. Our findings provide clear evidence that MAGV can cause human disease.
• Subjects:
  Bunyaviridae Infections Geography, Medical Humans Orthobunyavirus Phylogeny Phylogeography RNA, Viral Sequence Analysis, DNA Serotyping Whole Genome Sequencing
• Source:
  Emerg Infect Dis. 23(8):1325-1331.
• Pubmed ID:
  28726602
• Pubmed Central ID:
  PMC5547800
• Document Type:
  Journal Article
• Funding:
  HHSN272201000040I/AI/NIAID NIH HHS/United States
• Genre:
  Letters to the Editor
• Place as Subject:
  Peru ; Panama ; Argentina ; Ecuador ; Paraguay ; Colombia ; French Guiana ; United States ; Mexico ; Brazil ; Central America ; South America
• Volume:
  23
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:dcd3416465950aef2e6cd10664b9fc9ae6a0f837d4b5cb56ca8c9c5e566bbc3c
• Download URL:
  https://stacks.cdc.gov/view/cdc/47382/cdc_47382_DS1.pdf
• File Type:
  [PDF - 2.28 MB ]