Hodgkin lymphoma, HIV, and Epstein–Barr virus in Malawi: Longitudinal results from the Kamuzu Central Hospital Lymphoma study

Westmoreland, Katherine D.; Stanley, Christopher C.; Montgomery, Nathan D.; Kaimila, Bongani; Kasonkanji, Edwards; El-Mallawany, Nader Kim; Wasswa, Peter; Mtete, Idah; Butia, Mercy; Itimu, Salama; Chasela, Mary; Mtunda, Mary; Chikasema, Maria; Makwakwa, Victor; Kampani, Coxcilly; Dhungel, Bal M.; Sanders, Marcia K.; Krysiak, Robert; Tomoka, Tamiwe; Liomba, N. George; Dittmer, Dirk P.; Fedoriw, Yuri; Gopal, Satish

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Hodgkin lymphoma, HIV, and Epstein–Barr virus in Malawi: Longitudinal results from the Kamuzu Central Hospital Lymphoma study

Published Date:

Oct 26 2016

Source:

Pediatr Blood Cancer. 64(5).

Language:

English

[PDF-590.29 KB]

Details:

Personal Authors:

Westmoreland, Katherine D. ; Stanley, Christopher C. ; Montgomery, Nathan D. ; Kaimila, Bongani ; Kasonkanji, Edwards ; ... More ▼

Keywords:

[+]

Pubmed ID:

27781380

Pubmed Central ID:

PMC5529120

Description:

Background

Contemporary descriptions of classical Hodgkin lymphoma (cHL) are lacking from sub-Saharan Africa where human immunodeficiency virus (HIV) and Epstein–Barr virus (EBV) are prevalent.

Methods

We describe a prospective cHL cohort in Malawi enrolled from 2013 to 2015. Patients received standardized treatment and evaluation, including HIV status and EBV testing of tumors and plasma.

Results

Among 31 patients with confirmed cHL, the median age was 19 years (range, 2–51 years) and 22 (71%) were male. Sixteen patients (52%) had stage III/IV, 25 (81%) B symptoms, and 16 (52%) performance status impairment. Twenty-three patients (74%) had symptoms >6 months, and 11 of 29 (38%) had received empiric antituberculosis treatment. Anemia was common with median hemoglobin 8.2 g/dL (range, 3.1–17.1 g/dL), which improved during treatment. No children and 5 of 15 adults (33%)were HIV+. All HIV+ patients were on antiretroviral therapy for a median 15 months (range, 2–137 months), with median CD4 count 138 cells/μL (range, 23–329 cells/μL) and four (80%) having undetectable HIV. EBV was present in 18 of 24 (75%) tumor specimens, including 14 of 20 (70%) HIV− and 4 of 4 (100%) HIV+. Baseline plasma EBV DNA was detected in 25 of 28 (89%) patients, with median viral load 4.7 (range, 2.0–6.7) log10copies/mL, and subsequently declined in most patients. At 12 months, overall survival was 75% (95% confidence interval [CI], 55%–88%) and progression-free survival 65% (95% CI, 42%–81%). Baseline plasma EBV DNA and persistent viremia during treatment were associated with poorer outcomes.

Conclusion

cHL in Malawi is characterized by delayed diagnosis and advanced disease. Most cases were EBV associated and one-third of adults were HIV+. Despite resource limitations, 12-month outcomes were good.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

R21 CA180097/CA/NCI NIH HHS/United States
K01 TW009488/TW/FIC NIH HHS/United States
U54 CA190152/CA/NCI NIH HHS/United States
P20 CA210285/CA/NCI NIH HHS/United States
P30 AI050410/AI/NIAID NIH HHS/United States
R21 CA180815/CA/NCI NIH HHS/United States
U2G PS001965/PS/NCHHSTP CDC HHS/United States

Place as Subject:

Africa South of the Sahara ; Malawi ;

Main Document Checksum:

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Supporting Files:

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