Details:

Alternative Title:
Int J Cancer
Personal Author:
Westmoreland, Katherine D. ; Montgomery, Nathan D. ; Stanley, Christopher C. ; El-Mallawany, Nader Kim ; Wasswa, Peter ; ... More +
Westmoreland, Katherine D. ; Montgomery, Nathan D. ; Stanley, Christopher C. ; El-Mallawany, Nader Kim ; Wasswa, Peter ; van der Gronde, Toon ; Mtete, Idah ; Butia, Mercy ; Itimu, Salama ; Chasela, Mary ; Mtunda, Mary ; Kampani, Coxcilly ; Liomba, N. George ; Tomoka, Tamiwe ; Dhungel, Bal M. ; Sanders, Marcia K. ; Krysiak, Robert ; Kazembe, Peter ; Dittmer, Dirk P. ; Fedoriw, Yuri ; Gopal, Satish Less -
Description:
Point-of-care tools are needed in sub-Saharan Africa (SSA) to improve pediatric Burkitt lymphoma (BL) diagnosis and treatment. We evaluated plasma Epstein-Barr virus (pEBV) DNA as a pediatric BL biomarker in Malawi. Prospectively enrolled children with BL were compared to classical Hodgkin lymphoma (cHL) and nonlymphoma diagnoses. Pediatric BL patients received standardized chemotherapy and supportive care. pEBV DNA was measured at baseline, mid-treatment, and treatment completion. Of 121 assessed children, pEBV DNA was detected in 76/88 (86%) with BL, 16/17 (94%) with cHL, and 2/16 (12%) with nonlymphoma, with proportions higher in BL versus nonlymphoma (p < 0.001) and similar in BL versus cHL (p = 0.69). If detected, median pEBV DNA was 6.1 log| copies/mL for BL, 4.8 log| copies/mL for cHL, and 3.4 log| copies/mL for nonlymphoma, with higher levels in BL versus cHL (p = 0.029), and a trend toward higher levels in BL versus nonlymphoma (p = 0.062). pEBV DNA declined during treatment in the cohort overall and increased in several children before clinical relapse. Twelve-month overall survival was 40% in the cohort overall, and for children with baseline pEBV detected, survival was worse if baseline pEBV DNA was ≥6 log| copies/mL versus <6 log| copies/mL (p = 0.0002), and also if pEBV DNA was persistently detectable at mid-treatment versus undetectable (p = 0.041). Among children with baseline pEBV DNA detected, viremia was the only significant risk factor for death by 12 months in multivariate analyses (adjusted hazard ratio 1.35 per log| copies/mL, 95% CI 1.04-1.75, p = 0.023). Quantitative pEBV DNA has potential utility for diagnosis, prognosis, and response assessment for pediatric BL in SSA.
Subject:
[+]
Article Biomarkers, Tumor Burkitt Lymphoma Child DNA, Viral Epstein-Barr Virus Infections Female Herpesvirus 4, Human Hodgkin Disease Humans Male Neoplasm Recurrence, Local Plasma Prognosis Proportional Hazards Models Prospective Studies Viral Load
Source:
Int J Cancer. 140(11):2509-2516.
Pubmed ID:
28268254
Pubmed Central ID:
PMC5386821
Document Type:
Journal Article
Funding:
P01 CA019014/CA/NCI NIH HHS/United States ; K01 TW009488/TW/FIC NIH HHS/United States ; U54 CA190152/CA/NCI NIH HHS/United States ; R25 TW009340/TW/FIC NIH HHS/United States ; P30 CA016086/CA/NCI NIH HHS/United States ; ... More +
P01 CA019014/CA/NCI NIH HHS/United States ; K01 TW009488/TW/FIC NIH HHS/United States ; U54 CA190152/CA/NCI NIH HHS/United States ; R25 TW009340/TW/FIC NIH HHS/United States ; P30 CA016086/CA/NCI NIH HHS/United States ; U2G PS001965/PS/NCHHSTP CDC HHS/United States ; P30 AI050410/AI/NIAID NIH HHS/United States ; R21 CA180815/CA/NCI NIH HHS/United States Less -
Place as Subject:
Malawi
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f63bc6afaf3894f04dd0bb5ec300bb7deff81d1f9e745d6a05d2b6d52a175a9d
Download URL:
https://stacks.cdc.gov/view/cdc/45108/cdc_45108_DS1.pdf
File Type:

Supporting Files

• 	NIHMS857852-supplement-Supp_info.tif	tiff
  	nihms857852.nxml	xml
  	nihms857852f1.gif	gif
  	nihms857852f1.jpg	jpeg
  	nihms857852f2.gif	gif
  	nihms857852f2.jpg	jpeg

More +