MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015

Choe, Pyoeng Gyun; Perera, R.A.P.M.; Park, Wan Beom; Song, Kyoung-Ho; Bang, Ji Hwan; Kim, Eu Suk; Kim, Hong Bin; Ko, Long Wei Ronald; Park, Sang Won; Kim, Nam-Joong; Lau, Eric H.Y.; Poon, Leo L.M.; Peiris, Malik; Oh, Myoung-don

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MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015

Supporting Files Public Domain

Jul 15 2017
By Choe, Pyoeng Gyun ; Perera, R.A.P.M. ; Park, Wan Beom

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Choe, Pyoeng Gyun ; Perera, R.A.P.M. ; Park, Wan Beom ; Song, Kyoung-Ho ; Bang, Ji Hwan ; Kim, Eu Suk ; Kim, Hong Bin ; Ko, Long Wei Ronald ; Park, Sang Won ; Kim, Nam-Joong ; Lau, Eric H.Y. ; Poon, Leo L.M. ; Peiris, Malik ; Oh, Myoung-don
Description:

We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging.
Subjects:
Source:

Emerg Infect Dis. 23(7):1079-1084.
Pubmed ID:

28585916
Pubmed Central ID:

PMC5512479
Document Type:

Journal Article
Genre:

Historical Article
Place as Subject:

China ; Republic of Korea
Volume:

23
Issue:

7
Download URL:

https://stacks.cdc.gov/view/cdc/46776/cdc_46776_DS1.pdf
File Type:

[PDF - 1.17 MB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d3f298dd04052252392c3219a218b4137a0bff7a5780b93357c53357a1e3c226

File Language:

English

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