Measles Outbreak with Unique Virus Genotyping, Ontario, Canada, 2015

Thomas, Shari; Hiebert, Joanne; Gubbay, Jonathan B.; Gournis, Effie; Sharron, Jennifer; Severini, Alberto; Jiaravuthisan, Manisa; Shane, Amanda; Jaeger, Valerie; Crowcroft, Natasha S.; Fediurek, Jill; Sander, Beate; Mazzulli, Tony; Schulz, Helene; Deeks, Shelley L.

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Measles Outbreak with Unique Virus Genotyping, Ontario, Canada, 2015

Supporting Files Public Domain

Jul 2017
By Thomas, Shari ; Hiebert, Joanne ; Gubbay, Jonathan B. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Thomas, Shari ; Hiebert, Joanne ; Gubbay, Jonathan B. ; Gournis, Effie ; Sharron, Jennifer ; Severini, Alberto ; Jiaravuthisan, Manisa ; Shane, Amanda ; Jaeger, Valerie ; Crowcroft, Natasha S. ; Fediurek, Jill ; Sander, Beate ; Mazzulli, Tony ; Schulz, Helene ; Deeks, Shelley L.
Description:

The province of Ontario continues to experience measles virus transmissions despite the elimination of measles in Canada. We describe an unusual outbreak of measles in Ontario, Canada, in early 2015 that involved cases with a unique strain of virus and no known association among primary case-patients. A total of 18 cases of measles were reported from 4 public health units during the outbreak period (January 25-March 23, 2015); none of these cases occurred in persons who had recently traveled. Despite enhancements to case-patient interview methods and epidemiologic analyses, a source patient was not identified. However, the molecular epidemiologic analysis, which included extended sequencing, strongly suggested that all cases derived from a single importation of measles virus genotype D4. The use of timely genotype sequencing, rigorous epidemiologic investigation, and a better understanding of the gaps in surveillance are needed to maintain Ontario's measles elimination status.
Subjects:

Adolescent Adult Child Disease Outbreaks Female Genotype History, 21St Century Humans Male Measles/Diagnosis Measles/Epidemiology Measles/History Measles/Virology Measles Virus Public Health Surveillance Rna, Viral Sequence Analysis, DNA Serogroup Vaccination Young Adult
Source:

Emerg Infect Dis. 23(7):1063-1069.
Pubmed ID:

28628461
Pubmed Central ID:

PMC5512469
Document Type:

Journal Article
Genre:

Historical Article
Place as Subject:

Ontario, Canada
Volume:

23
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:e69028d19b42313cbb67de0629c7e6cad38435146501e4ed3a6ec2179c59747d
Download URL:

https://stacks.cdc.gov/view/cdc/46748/cdc_46748_DS1.pdf
File Type:

[PDF - 573.41 KB ]

File Language:

English

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