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Prostate cancer characteristics in the World Trade Center cohort, 2002-2013
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July 2018
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Source: Eur J Cancer Prev. 27(4):347-354
Details:
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Alternative Title:Eur J Cancer Prev
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Personal Author:
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Description:Background
An increased incidence of prostate cancer was reported in three cohorts of World Trade Center (WTC) respondents. It is uncertain whether this increase is due to WTC-related exposures or enhanced surveillance.
Methods
Prostate cancer cases (2002-2013) were obtained from the WTC Health Program. Age, race and Gleason score distribution were compared to New York State Cancer Registry (NYSCR) cases from the same time period. Multivariate models were adjusted for age and race. Analyses of clinical characteristics of prostate cancer cases within the cohort were also performed, adjusting for age, race, and WTC exposure categories.
Results
WTC respondents had a prostate cancer age-standardized rate ratio of 1.65 (95% CI: 1.37, 1.93) compared to New York state; age-specific ratios were highest for ages 30-49 (2.28; 95% CI: 1.51-3.43), 70-74 (2.05; 95% CI: 1.03-4.10), and 80-84 years (5.65; 95% CI: 1.41-22.58). High WTC exposure was associated with advanced clinical stage (5.58; 95% CI: 1.05-29.76; p-trend=0.03).
Conclusions
WTC respondents continue to have higher prostate cancer rate compared to NYS as a whole. Respondents with a higher WTC exposure level may have had more advanced clinical stage of prostate cancer.
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Pubmed ID:27898584
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Pubmed Central ID:PMC5443704
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Volume:27
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Issue:4
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