Prostate cancer characteristics in the World Trade Center cohort, 2002-2013

Details

• Personal Author:
  Boffetta P ; Crane M ; Galsky M ; Harrison D ; Hashim D ; Lucchini R ; Luft B ; Moline J ; Oh W ; Taioli E ; Udasin I
• Description:
  An increased incidence of prostate cancer was reported in three cohorts of World Trade Center (WTC) respondents. It is uncertain whether this increase is because of WTC-related exposures or enhanced surveillance. Prostate cancer cases (2002-2013) were obtained from the WTC Health Program. Age, race, and Gleason score distribution were compared with New York State Cancer Registry cases from the same time period. Multivariate models were adjusted for age and race. Analyses of clinical characteristics of prostate cancer cases within the cohort were also carried out, adjusting for age, race, and WTC exposure categories. WTC respondents had a prostate cancer age-standardized rate ratio of 1.65 [95% confidence interval (CI): 1.37-1.93] compared with New York State; age-specific ratios were highest for ages 30-49 (2.28; 95% CI: 1.51-3.43), 70-74 (2.05; 95% CI: 1.03-4.10), and 80-84 years (5.65; 95% CI: 1.41-22.58). High WTC exposure was associated with advanced clinical stage (5.58; 95% CI: 1.05-29.76; Ptrend=0.03). WTC respondents continue to have a higher prostate cancer rate compared with New York State as a whole. Respondents with a higher WTC exposure level may have had more advanced clinical stage of prostate cancer. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Dust Epidemiology Hazardous Substances Health Promotion Neoplasms Occupational Health Race Factors Safety September 11 Terrorist Attacks

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• Keywords:
  Age Factors Age Groups Author Keywords: Disasters Cancer Cancer Rates Cancer Registries Disaster Response Dust Exposure Health Programs Information Retrieval Systems New York City Prostate Cancer Prostate Neoplasms Racial Factors September 11 Terrorist Attacks Statistical Analysis Surveillance Surveillance Programs Toxic Materials Urogenital System Disorders World Trade Center WTC

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• ISSN:
  0959-8278
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  347-354
• Volume:
  27
• Issue:
  4
• NIOSHTIC Number:
  nn:20048992
• Citation:
  Eur J Cancer Prev 2018 Jul; 27(4):347-354
• Contact Point Address:
  Dana Hashim, MD, MS, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, One Gustav L Levy Place New York, NY 10029, USA
• Email:
  dana.hashim@mssm.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20130701
• Source Full Name:
  European Journal of Cancer Prevention
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:adb20dfa4b062d3026d98ad97a17b83f144d7586ac2b095153965e4a17cd046194dcbd63e30cfaa7ec44e81558aa631d7958b208de2d0432a2f334b171a2ae04
• Download URL:
  https://stacks.cdc.gov/view/cdc/203595/cdc_203595_DS1.pdf
• File Type:
  [PDF - 147.92 KB ]