Insecticide-Treated Nets and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ochomo, Eric ; Chahilu, Mercy ; Cook, Jackie ; Kinyari, Teresa ; Bayoh, Nabie M. ; West, Philippa ; Kamau, Luna ; Osangale, Aggrey ; Ombok, Maurice ; Njagi, Kiambo ; Mathenge, Evan ; Muthami, Lawrence ; Subramaniam, Krishanthi ; Knox, Tessa ; Mnavaza, Abraham ; Donnelly, Martin James ; Kleinschmidt, Immo ; Mbogo, Charles
• Description:
  Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9-2.5) infections/person-year and 2.8 (95% CI 2.5-3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42-0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35-0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance.
• Subjects:
  Animals Child Child, Preschool Cohort Studies Female Follow-Up Studies Humans Incidence Infant Insecticide-Treated Bednets Insecticide Resistance Insecticides Malaria Male Mosquito Control Mosquito Vectors Public Health Surveillance

  More +
• Source:
  Emerg Infect Dis. 23(5):758-764.
• Pubmed ID:
  28418293
• Pubmed Central ID:
  PMC5403037
• Document Type:
  Journal Article
• Place as Subject:
  Kenya
• Volume:
  23
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:baaee9f7293eb1e858bf0c41c557da02c18b4acb98284fa7c57e8d20c30aeb70
• Download URL:
  https://stacks.cdc.gov/view/cdc/45620/cdc_45620_DS1.pdf
• File Type:
  [PDF - 928.27 KB ]