High Plasmodium Infection Rate and Reduced Bed Net Efficacy in Multiple Insecticide-Resistant Malaria Vectors in Kinshasa, Democratic Republic of Congo

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Riveron, Jacob M ; Watsenga, Francis ; Irving, Helen ; Irish, Seth R ; Wondji, Charles S ; Riveron, Jacob M ; Watsenga, Francis ; Irving, Helen ; Irish, Seth R ; Wondji, Charles S
• Description:
  Accounting for approximately 11% of all malaria cases, the Democratic Republic of the Congo (DRC) is central to malaria elimination efforts. To support vector control interventions in DRC, we characterized the dynamics and impact of insecticide resistance in major malaria vectors in 2015. High Plasmodium infection rates were recorded in Anopheles gambiae and Anopheles funestus, with Plasmodium falciparum predominant over Plasmodium malariae. Both mosquito species exhibited high and multiple resistance to major public health insecticide classes. The extremely high resistance to permethrin and DDT (dichlorodiphenyltrichloroethane) in An. gambiae (low mortalities after 6 hours exposure) is worrisome, and is supported by a reduced insecticidal effect of bed nets against both mosquito species in laboratory tests. Metabolic and target site insensitivity mechanisms are driving this resistance in An. gambiae, but only the former was observed in An. funestus. These findings highlight the urgent need for actions to prolong the effectiveness of insecticide-based interventions in DRC.
• Subjects:
  Animals Anopheles DDT Disease Transmission, Infectious Female Insecticide-Treated Bednets Insecticide Resistance Insecticides Malaria Male Mosquito Control Mosquito Vectors Permethrin Plasmodium Sensitivity And Specificity

  More +
• Source:
  J Infect Dis. 2017; 217(2):320-328. ; J Infect Dis. 2017; 217(2):320-328.
• Pubmed ID:
  29087484
• Pubmed Central ID:
  PMC5853898
• Document Type:
  Journal Article
• Place as Subject:
  Democratic Republic of the Congo
• Volume:
  217
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:db21045c7b5296dcb515587eacbb4257ebfbba1e9ac9a0a237a6107b5eab43e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/52805/cdc_52805_DS1.pdf
• File Type:
  [PDF - 1.05 MB ]