Transmission of Hepatitis A Virus through Combined Liver–Small Intestine–Pancreas Transplantation

Foster, Monique A.; Weil, Lauren M.; Jin, Sherry; Johnson, Thomas; Hayden-Mixson, Tonya R.; Khudyakov, Yury; Annambhotla, Pallavi D.; Basavaraju, Sridhar V.; Kamili, Saleem; Ritter, Jana M.; Nelson, Noele; Mazariegos, George; Green, Michael; Himes, Ryan W.; Kuhar, David T.; Kuehnert, Matthew J.; Miller, Jeffrey A.; Wiseman, Rachel; Moorman, Anne C.

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Transmission of Hepatitis A Virus through Combined Liver–Small Intestine–Pancreas Transplantation

Supporting Files Public Domain

Apr 2017
By Foster, Monique A. ; Weil, Lauren M. ; Jin, Sherry ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Foster, Monique A. ; Weil, Lauren M. ; Jin, Sherry ; Johnson, Thomas ; Hayden-Mixson, Tonya R. ; Khudyakov, Yury ; Annambhotla, Pallavi D. ; Basavaraju, Sridhar V. ; Kamili, Saleem ; Ritter, Jana M. ; Nelson, Noele ; Mazariegos, George ; Green, Michael ; Himes, Ryan W. ; Kuhar, David T. ; Kuehnert, Matthew J. ; Miller, Jeffrey A. ; Wiseman, Rachel ; Moorman, Anne C.
Description:

Although transmission of hepatitis A virus (HAV) through blood transfusion has been documented, transmission through organ transplantation has not been reported. In August 2015, state health officials in Texas, USA, were notified of 2 home health nurses with HAV infection whose only common exposure was a child who had undergone multi-visceral organ transplantation 9 months earlier. Specimens from the nurses, organ donor, and all organ recipients were tested and medical records reviewed to determine a possible infection source. Identical HAV RNA sequences were detected from the serum of both nurses and the organ donor, as well as from the multi-visceral organ recipient's serum and feces; this recipient's posttransplant liver and intestine biopsy specimens also had detectable virus. The other organ recipients tested negative for HAV RNA. Vaccination of the donor might have prevented infection in the recipient and subsequent transmission to the healthcare workers.
Subjects:

Adult Child Hepatitis A Hepatitis A Virus Humans Infectious Disease Transmission, Patient-To-Professional Nurses Organ Transplantation Synopsis Transplant Recipients
Source:

Emerg Infect Dis. 23(4):590-596.
Pubmed ID:

28322704
Pubmed Central ID:

PMC5367420
Document Type:

Journal Article
Volume:

23
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:1e451146d012b25467ce4d976fcd124268b59331889c57c78c3a2e8b20ecda0b
Download URL:

https://stacks.cdc.gov/view/cdc/45027/cdc_45027_DS1.pdf
File Type:

[PDF - 740.56 KB ]

File Language:

English

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