Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Lo, Eugenia ; Nguyen, Kristie ; Nguyen, Jennifer ; Hemming-Schroeder, Elizabeth ; Xu, Jiaobao ; ... More +
Lo, Eugenia ; Nguyen, Kristie ; Nguyen, Jennifer ; Hemming-Schroeder, Elizabeth ; Xu, Jiaobao ; Etemesi, Harrisone ; Githeko, Andrew ; Yan, Guiyun Less -
Description:
In Africa, control programs that target primarily Plasmodium falciparum are inadequate for eliminating malaria. To learn more about prevalence and genetic variability of P. malariae in Africa, we examined blood samples from 663 asymptomatic and 245 symptomatic persons from western Kenya during June-August of 2014 and 2015. P. malariae accounted for 5.3% (35/663) of asymptomatic infections and 3.3% (8/245) of clinical cases. Among asymptomatic persons, 71% (32/45) of P. malariae infections detected by PCR were undetected by microscopy. The low sensitivity of microscopy probably results from the significantly lower parasitemia of P. malariae. Analyses of P. malariae circumsporozoite protein gene sequences revealed high genetic diversity among P. malariae in Africa, but no clear differentiation among geographic populations was observed. Our findings suggest that P. malariae should be included in the malaria elimination strategy in Africa and highlight the need for sensitive and field-applicable methods to identify P. malariae in malaria-endemic areas.
Subject:
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Circumsporozoite Protein Diversity Co-infections Csp Diagnostic Sensitivity Malaria Microscopy Nested PCR Parasite Gene Copy Number Parasites Plasmodium Malariae Plasmodium Malariae Prevalence And Csp Gene Diversity, Kenya, 2014 And 2015 Research
Source:
Emerg Infect Dis. 23(4):601-610.
Pubmed ID:
28322694
Pubmed Central ID:
PMC5367407
Document Type:
Journal Article
Funding:
D43 TW001505/TW/FIC NIH HHS/United States ; R01 AI050243/AI/NIAID NIH HHS/United States
D43 TW001505/TW/FIC NIH HHS/United States ; R01 AI050243/AI/NIAID NIH HHS/United States Less -
Place as Subject:
Kenya
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:12cb33c4c0767a6f97cd5d3a8b7ac68713ad2e12f2ffecbf1eb8e760b9e23f90
Download URL:
https://stacks.cdc.gov/view/cdc/45022/cdc_45022_DS1.pdf
File Type:

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