Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Scott, Colleen ; Cavanaugh, Joseph S. ; Silk, Benjamin J. ; Ershova, Julia ; Mazurek, Gerald H. ; ... More +
Scott, Colleen ; Cavanaugh, Joseph S. ; Silk, Benjamin J. ; Ershova, Julia ; Mazurek, Gerald H. ; LoBue, Philip A. ; Moonan, Patrick K. Less -
Description:
Current US guidelines recommend longer treatment for tuberculosis (TB) caused by pyrazinamide-resistant organisms (e.g., Mycobacterium bovis) than for M. tuberculosis TB. We compared treatment response times for patients with M. bovis TB and M. tuberculosis TB reported in the United States during 2006-2013. We included culture-positive, pulmonary TB patients with genotyping results who received standard 4-drug treatment at the time of diagnosis. Time to sputum-culture conversion was defined as time between treatment start date and date of first consistently culture-negative sputum. We analyzed 297 case-patients with M. bovis TB and 30,848 case-patients with M. tuberculosis TB. After 2 months of treatment, 71% of M. bovis and 65% of M. tuberculosis TB patients showed conversion of sputum cultures to negative. Likelihood of culture conversion was higher for M. bovis than for M. tuberculosis, even after controlling for treatment administration type, sex, and a composite indicator of bacillary burden.
Subject:
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Bacteria Comparison Of Sputum-Culture Conversion For Mycobacterium Bovis And M. Tuberculosis Disease Mycobacterium Bovis Mycobacterium Tuberculosis Research Sputum Sputum-Culture Conversion Tuberculosis Tuberculosis And Other Mycobacteria
Source:
Emerg Infect Dis. 23(3):456-462.
Pubmed ID:
28221125
Pubmed Central ID:
PMC5382750
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:a527fffea3bc11b8b6b3fbd413e0d94e9b2268b56d6a4a46e97f6e369cb9f47c
Download URL:
https://stacks.cdc.gov/view/cdc/44956/cdc_44956_DS1.pdf
File Type:

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