pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Allana, Salim ; Shashkina, Elena ; Mathema, Barun ; Bablishvili, Nino ; Tukvadze, Nestani ; Shah, N. Sarita ; Kempker, Russell R. ; Blumberg, Henry M. ; Moodley, Pravi ; Mlisana, Koleka ; Brust, James C.M. ; Gandhi, Neel R.
• Description:
  Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis.
• Subjects:
  Amidohydrolases Antitubercular Agents Dispatch Drug Resistance, Multiple, Bacteria Extensively Drug-Resistant Tuberculosis Humans Mutation Pyrazinamide
• Source:
  Emerg Infect Dis. 23(3):491-495.
• Pubmed ID:
  28221108
• Pubmed Central ID:
  PMC5382742
• Document Type:
  Journal Article
• Funding:
  P30 AI050409/AI/NIAID NIH HHS/United States ; R21 AI122001/AI/NIAID NIH HHS/United States ; D43 TW007124/TW/FIC NIH HHS/United States ; R01 AI089349/AI/NIAID NIH HHS/United States ; UL1 TR000454/TR/NCATS NIH HHS/United States ; UL1 TR001073/TR/NCATS NIH HHS/United States ; K23 AI103044/AI/NIAID NIH HHS/United States ; R01 AI087465/AI/NIAID NIH HHS/United States ; K24 AI114444/AI/NIAID NIH HHS/United States ; K23 AI083088/AI/NIAID NIH HHS/United States
• Place as Subject:
  South Africa ; Georgia (Republic)
• Location:
  Africa ; Europe
• Volume:
  23
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3b84aa2cf8ca016a76d38aa8698baf669ca3fe4aea6081deac65a9fa2f7dc49e
• Download URL:
  https://stacks.cdc.gov/view/cdc/44927/cdc_44927_DS1.pdf
• File Type:
  [PDF - 750.76 KB ]