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pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia
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Mar 2017
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Source: Emerg Infect Dis. 23(3):491-495.
[PDF-750.76 KB]
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Alternative Title:Emerg Infect Dis
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Description:Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis.
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Pubmed ID:28221108
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Pubmed Central ID:PMC5382742
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Volume:23
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Issue:3
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