pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia

Allana, Salim; Shashkina, Elena; Mathema, Barun; Bablishvili, Nino; Tukvadze, Nestani; Shah, N. Sarita; Kempker, Russell R.; Blumberg, Henry M.; Moodley, Pravi; Mlisana, Koleka; Brust, James C.M.; Gandhi, Neel R.

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pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia

Mar 2017
By Allana, Salim ; Shashkina, Elena ; Mathema, Barun ; ...
Source: Emerg Infect Dis. 23(3):491-495.

[PDF-750.76 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Allana, Salim ; Shashkina, Elena ; Mathema, Barun ; Bablishvili, Nino ; Tukvadze, Nestani ; ... More +

Allana, Salim ; Shashkina, Elena ; Mathema, Barun ; Bablishvili, Nino ; Tukvadze, Nestani ; Shah, N. Sarita ; Kempker, Russell R. ; Blumberg, Henry M. ; Moodley, Pravi ; Mlisana, Koleka ; Brust, James C.M. ; Gandhi, Neel R. Less -
Description:

Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis.
Subjects:

[+]

Amidohydrolases Antitubercular Agents Dispatch Drug Resistance, Multiple, Bacteria Extensively Drug-Resistant Tuberculosis Humans Mutation Pyrazinamide
Source:

Emerg Infect Dis. 23(3):491-495.
Pubmed ID:

28221108
Pubmed Central ID:

PMC5382742
Document Type:

Journal Article
Funding:

P30 AI050409/AI/NIAID NIH HHS/United States ; R21 AI122001/AI/NIAID NIH HHS/United States ; D43 TW007124/TW/FIC NIH HHS/United States ; R01 AI089349/AI/NIAID NIH HHS/United States ; UL1 TR000454/TR/NCATS NIH HHS/United States ; ... More +

P30 AI050409/AI/NIAID NIH HHS/United States ; R21 AI122001/AI/NIAID NIH HHS/United States ; D43 TW007124/TW/FIC NIH HHS/United States ; R01 AI089349/AI/NIAID NIH HHS/United States ; UL1 TR000454/TR/NCATS NIH HHS/United States ; UL1 TR001073/TR/NCATS NIH HHS/United States ; K23 AI103044/AI/NIAID NIH HHS/United States ; R01 AI087465/AI/NIAID NIH HHS/United States ; K24 AI114444/AI/NIAID NIH HHS/United States ; K23 AI083088/AI/NIAID NIH HHS/United States Less -
Place as Subject:

South Africa ; Georgia (Republic)

South Africa ; Georgia (Republic) Less -
Location:

Africa ; Europe

Africa ; Europe Less -
Volume:

23
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:3b84aa2cf8ca016a76d38aa8698baf669ca3fe4aea6081deac65a9fa2f7dc49e
Download URL:

https://stacks.cdc.gov/view/cdc/44927/cdc_44927_DS1.pdf
File Type:

	16-1034-Techapp-s1.pdf	pdf
	16-1034.nxml	bin

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