Details:

Alternative Title:
Cancer Epidemiol Biomarkers Prev
Personal Author:
Devore, Elizabeth E. ; Warner, Erica T. ; Eliassen, A. Heather ; Brown, Susan B. ; Beck, Andrew H. ; ... More +
Devore, Elizabeth E. ; Warner, Erica T. ; Eliassen, A. Heather ; Brown, Susan B. ; Beck, Andrew H. ; Hankinson, Susan E. ; Schernhammer, Eva S. Less -
Description:
Background

Urinary melatonin levels have been associated with a reduced risk of breast cancer in postmenopausal women, but this association might vary according to tumor melatonin 1 receptor (MT1R) expression.

Methods

We conducted a nested case-control study among 1,354 postmenopausal women in the Nurses’ Health Study, who were cancer free when they provided first-morning spot urine samples in 2000–2002; urine samples were assayed for 6-sulfatoxymelatonin (aMT6s, a major metabolite of melatonin). Five-hundred fifty-five of these women developed breast cancer before May 31, 2012, and were matched to 799 control subjects. In a subset of cases, immunohistochemistry was used to determine MT1R status of tumor tissue. We used multivariable-adjusted conditional logistic regression to estimate the relative risk (RR) of breast cancer (with 95% confidence intervals [CI]) across quartiles of creatinine-standardized urinary aMT6s level, including by MT1R subtype.

Results

Higher urinary melatonin levels were suggestively associated with a lower overall risk of breast cancer (multivariable-adjusted RR=0.78, 95% CI=0.61–0.99, comparing quartile 4 vs. quartile 1; p-trend=0.08); this association was similar for invasive vs. in situ tumors (p-heterogeneity=0.12). There was no evidence that associations differed according to MT1R status of the tumor (e.g., p-heterogeneity for overall breast cancer=0.88).

Conclusion

Higher urinary melatonin levels were associated with reduced breast cancer risk in this cohort of postmenopausal women, and the association was not modified by MT1R subtype.

Impact

Urinary melatonin levels appear to predict the risk of breast cancer in postmenopausal women. However, future research should evaluate these associations with longer-term follow-up and among premenopausal women.


Subject:
[+]
Aged
Article
Biomarkers, Tumor
Breast Cancer
Breast Neoplasms
Case-Control Studies
Creatine
Epidemiology
Female
Humans
Incidence
Logistic Models
Longitudinal Studies
Melatonin
Melatonin 1 Receptor
Middle Aged
Postmenopausal
Postmenopause
Receptor, Melatonin, MT1
Risk Factors

Source:
Cancer Epidemiol Biomarkers Prev. 26(3):413-419.
Pubmed ID:
28151704
Pubmed Central ID:
PMC5336486
Document Type:
Journal Article
Funding:
P01 CA087969/CA/NCI NIH HHS/United States ; R01 OH009803/OH/NIOSH CDC HHS/United States ; UM1 CA186107/CA/NCI NIH HHS/United States
P01 CA087969/CA/NCI NIH HHS/United States ; R01 OH009803/OH/NIOSH CDC HHS/United States ; UM1 CA186107/CA/NCI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5c23df01b74c29ec69fe5204db303a25cd4580d8abffac0dd59a4e8f7e112552
File Type:

Supporting Files

• 	NIHMS829152-supplement-1.doc	doc
  	nihms829152.nxml	xml

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