Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Du, Pengcheng ; Zheng, Han ; Zhou, Jieping ; Lan, Ruiting ; Ye, Changyun ; ... More +
Du, Pengcheng ; Zheng, Han ; Zhou, Jieping ; Lan, Ruiting ; Ye, Changyun ; Jing, Huaiqi ; Jin, Dong ; Cui, Zhigang ; Bai, Xuemei ; Liang, Jianming ; Liu, Jiantao ; Xu, Lei ; Zhang, Wen ; Chen, Chen ; Xu, Jianguo Less -
Description:
Streptococcus suis sequence type 7 emerged and caused 2 of the largest human infection outbreaks in China in 1998 and 2005. To determine the major risk factors and source of the infections, we analyzed whole genomes of 95 outbreak-associated isolates, identified 160 single nucleotide polymorphisms, and classified them into 6 clades. Molecular clock analysis revealed that clade 1 (responsible for the 1998 outbreak) emerged in October 1997. Clades 2-6 (responsible for the 2005 outbreak) emerged separately during February 2002-August 2004. A total of 41 lineages of S. suis emerged by the end of 2004 and rapidly expanded to 68 genome types through single base mutations when the outbreak occurred in June 2005. We identified 32 identical isolates and classified them into 8 groups, which were distributed in a large geographic area with no transmission link. These findings suggest that persons were infected in parallel in respective geographic sites.
Subject:
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Animals Breeding Disease Outbreaks Genome, Bacterial Genomics Genotype Geographic Mapping History, 21st Century Humans Mutation Phylogeny Phylogeography Polymorphism, Single Nucleotide Research Risk Factors Streptococcal Infections Streptococcus Suis Swine Swine Diseases Whole Genome Sequencing
Source:
Emerg Infect Dis. 23(2):204-211.
Pubmed ID:
27997331
Pubmed Central ID:
PMC5324821
Document Type:
Journal Article
Place as Subject:
China
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:c5e21240e411accbf31f74eb95d15e486bfe9485f116652373fad503fff63a81
Download URL:
https://stacks.cdc.gov/view/cdc/44360/cdc_44360_DS1.pdf
File Type:

Supporting Files

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  	16-0297-Techapp-s2.pdf	pdf
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