A newly emerged swine origin A(H3N2)v influenza virus dampens host antiviral immunity but induces potent inflammasome activation
Published Date:Jun 11 2015
Source:J Infect Dis. 212(12):1923-1929.
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Myeloid Dendritic Cell
Type I IFN
Pubmed Central ID:PMC5240150
Funding:CC999999/Intramural CDC HHS/United States
Description:We compared the innate immune response to a newly emerged swine-origin influenza A(H3N2) variant containing the M gene from 2009 pandemic influenza A(H1N1), termed "A(H3N2)vpM," to the immune responses to the 2010 swine-origin influenza A(H3N2) variant and seasonal influenza A(H3N2). Our results demonstrated that A(H3N2)vpM-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of proinflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.
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