Details:

Alternative Title:
J Infect Dis
Personal Author:
Cao, Weiping ; Mishina, Margarita ; Ranjan, Priya ; De La Cruz, Juan A. ; Kim, Jin Hyang ; ... More +
Cao, Weiping ; Mishina, Margarita ; Ranjan, Priya ; De La Cruz, Juan A. ; Kim, Jin Hyang ; Garten, Rebecca ; Kumar, Amrita ; García-Sastre, Adolfo ; Katz, Jacqueline M. ; Gangappa, Shivaprakash ; Sambhara, Suryaprakash Less -
Description:
We compared the innate immune response to a newly emerged swine-origin influenza A(H3N2) variant containing the M gene from 2009 pandemic influenza A(H1N1), termed "A(H3N2)vpM," to the immune responses to the 2010 swine-origin influenza A(H3N2) variant and seasonal influenza A(H3N2). Our results demonstrated that A(H3N2)vpM-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of proinflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.
Subject:
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A(H3N2)vpM
Animals
Article
Cell Line
Cytokines
Dendritic Cells
Humans
Inflammasome Activation
Inflammasomes
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Leukocytes, Mononuclear
Myeloid Dendritic Cell
Orthomyxoviridae Infections
Pro-inflammatory Cytokines
ROS
Swine
Swine Diseases
Type I IFN

Source:
J Infect Dis. 212(12):1923-1929.
Pubmed ID:
26068782
Pubmed Central ID:
PMC5240150
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:6519a011d8910400610bf23241fcf1a5e089b83ba95abffb6c13729349b42e41
File Type:

Supporting Files

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  	NIHMS750995-supplement-01.docx	docx
  	NIHMS750995-supplement-Supplementary_figures.pdf	pdf
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