A newly emerged swine origin A(H3N2)v influenza virus dampens host antiviral immunity but induces potent inflammasome activation

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Cao, Weiping ; Mishina, Margarita ; Ranjan, Priya ; De La Cruz, Juan A. ; Kim, Jin Hyang ; Garten, Rebecca ; Kumar, Amrita ; García-Sastre, Adolfo ; Katz, Jacqueline M. ; Gangappa, Shivaprakash ; Sambhara, Suryaprakash
• Description:
  We compared the innate immune response to a newly emerged swine-origin influenza A(H3N2) variant containing the M gene from 2009 pandemic influenza A(H1N1), termed "A(H3N2)vpM," to the immune responses to the 2010 swine-origin influenza A(H3N2) variant and seasonal influenza A(H3N2). Our results demonstrated that A(H3N2)vpM-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of proinflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.
• Subjects:
  A(H3N2)vpM Animals Article Cell Line Cytokines Dendritic Cells Humans Inflammasome Activation Inflammasomes Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Leukocytes, Mononuclear Myeloid Dendritic Cell Orthomyxoviridae Infections Pro-inflammatory Cytokines ROS Swine Swine Diseases Type I IFN

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• Source:
  J Infect Dis. 212(12):1923-1929.
• Pubmed ID:
  26068782
• Pubmed Central ID:
  PMC5240150
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  212
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6519a011d8910400610bf23241fcf1a5e089b83ba95abffb6c13729349b42e41
• Download URL:
  https://stacks.cdc.gov/view/cdc/43862/cdc_43862_DS1.pdf
• File Type:
  [PDF - 1.36 MB ]