A newly emerged swine origin A(H3N2)v influenza virus dampens host antiviral immunity but induces potent inflammasome activation

Cao, Weiping; Mishina, Margarita; Ranjan, Priya; De La Cruz, Juan A.; Kim, Jin Hyang; Garten, Rebecca; Kumar, Amrita; García-Sastre, Adolfo; Katz, Jacqueline M.; Gangappa, Shivaprakash; Sambhara, Suryaprakash

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A newly emerged swine origin A(H3N2)v influenza virus dampens host antiviral immunity but induces potent inflammasome activation

Published Date:

Jun 11 2015

Source:

J Infect Dis. 212(12):1923-1929.

[PDF - 1.36 MB]

Details:

Personal Authors:

Cao, Weiping ; Mishina, Margarita ; Ranjan, Priya ; De La Cruz, Juan A. ; Kim, Jin Hyang ; ... More ▼

Keywords:

[+]

Pubmed ID:

26068782

Pubmed Central ID:

PMC5240150

Description:

We compared the innate immune response to a newly emerged swine-origin influenza A(H3N2) variant containing the M gene from 2009 pandemic influenza A(H1N1), termed "A(H3N2)vpM," to the immune responses to the 2010 swine-origin influenza A(H3N2) variant and seasonal influenza A(H3N2). Our results demonstrated that A(H3N2)vpM-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of proinflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Supporting Files:

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NIHMS750995-supplement-Supplementary_figures.pdf	application/pdf
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