2004–2014

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Weyer, Camilla T. ; Grewar, John D. ; Burger, Phillippa ; Rossouw, Esthea ; Lourens, Carina ; Joone, Christopher ; le Grange, Misha ; Coetzee, Peter ; Venter, Estelle ; Martin, Darren P. ; MacLachlan, N. James ; Guthrie, Alan J.
• Description:
  African horse sickness (AHS) is a hemorrhagic viral fever of horses. It is the only equine disease for which the World Organization for Animal Health has introduced specific guidelines for member countries seeking official recognition of disease-free status. Since 1997, South Africa has maintained an AHS controlled area; however, sporadic outbreaks of AHS have occurred in this area. We compared the whole genome sequences of 39 AHS viruses (AHSVs) from field AHS cases to determine the source of 3 such outbreaks. Our analysis confirmed that individual outbreaks were caused by virulent revertants of AHSV type 1 live, attenuated vaccine (LAV) and reassortants with genome segments derived from AHSV types 1, 3, and 4 from a LAV used in South Africa. These findings show that despite effective protection of vaccinated horses, polyvalent LAV may, paradoxically, place susceptible horses at risk for AHS.
• Subjects:
  African Horse Sickness African Horse Sickness/history African Horse Sickness Virus Animals Disease Outbreaks Genome, Viral Genotype History, 21st Century Horses Phylogeny Polymorphism, Single Nucleotide Reassortant Viruses Serotyping Vaccines, Attenuated Viral Vaccines Whole Genome Sequencing

  More +
• Source:
  Emerg Infect Dis. 22(12):2087-2096.
• Pubmed ID:
  27442883
• Pubmed Central ID:
  PMC5189153
• Document Type:
  Journal Article
• Place as Subject:
  South Africa
• Volume:
  22
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8773d17db652e7f26fc8947d31bf22bf5e0ad1bcba13e4a3dee20c06b626ad02
• Download URL:
  https://stacks.cdc.gov/view/cdc/43445/cdc_43445_DS1.pdf
• File Type:
  [PDF - 4.79 MB ]